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- NCIT_C47717 IAO_0000115 "A fluorinated isopropyl ether with general anesthetic property. Although the mechanism of action has not been fully elucidated, sevoflurane may act by interfering with the release and re-uptake of neurotransmitters at post-synaptic terminals, and/or alter ionic conductance following receptor activation by a neurotransmitter. Sevoflurane may also interact directly with lipid matrix of neuronal membranes, thereby affecting gating properties of ion channels. In addition, this agent may activate gamma-aminobutyric acid (GABA) receptors hyperpolarizing cell membranes. This results in a general anesthetic effect, a decrease in myocardial contractility and mean arterial pressure as well as an increased respiratory rate." @default.
- NCIT_C47717 NCIT_NHC0 "C47717" @default.
- NCIT_C47717 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47717 NCIT_P108 "Sevoflurane" @default.
- NCIT_C47717 NCIT_P207 "C0074414" @default.
- NCIT_C47717 NCIT_P210 "28523-86-6" @default.
- NCIT_C47717 NCIT_P319 "38LVP0K73A" @default.
- NCIT_C47717 NCIT_P322 "FDA" @default.
- NCIT_C47717 NCIT_P329 "524061" @default.
- NCIT_C47717 NCIT_P330 "524061" @default.
- NCIT_C47717 NCIT_P350 "C4H3F7O" @default.
- NCIT_C47717 NCIT_P366 "Sevoflurane" @default.
- NCIT_C47717 NCIT_P368 "CHEBI:9130" @default.
- NCIT_C47717 NCIT_P399 "524061" @default.
- NCIT_C47717 normalizedInformationContent "100" @default.
- NCIT_C47717 referenceCount "1" @default.
- NCIT_C47717 hasExactSynonym "1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane" @default.
- NCIT_C47717 hasExactSynonym "Ether, Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl-" @default.
- NCIT_C47717 hasExactSynonym "SEVOFLURANE" @default.
- NCIT_C47717 hasExactSynonym "Sevoflurane" @default.
- NCIT_C47717 hasExactSynonym "Ultane" @default.
- NCIT_C47717 inSubset NCIT_C173381 @default.
- NCIT_C47717 inSubset NCIT_C173383 @default.
- NCIT_C47717 inSubset NCIT_C176424 @default.
- NCIT_C47717 inSubset NCIT_C63923 @default.
- NCIT_C47717 type Class @default.
- NCIT_C47717 isDefinedBy ncit.owl @default.
- NCIT_C47717 label "Sevoflurane" @default.
- NCIT_C47717 subClassOf NCIT_C1908 @default.
- NCIT_C47717 subClassOf NCIT_C1909 @default.
- NCIT_C47717 subClassOf NCIT_C245 @default.
- NCIT_C47717 subClassOf NCIT_C47717 @default.
- NCIT_C47717 subClassOf NCIT_C78272 @default.