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- NCIT_C47733 IAO_0000115 "The nitrate salt form of sulconazole, a synthetic imidazole derivative with antifungal property. Sulconazole nitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols and inhibition of the synthesis of ergosterol, an important component of the fungal cell membrane. Inhibition of ergosterol synthesis leads to a disruption of cell membrane permeability, and ultimately inhibition of cell wall synthesis. In addition, sulconazole nitrate seems to interfere with the autolytic degradation of fungal DNA and RNA." @default.
- NCIT_C47733 NCIT_A6 NCIT_C61958 @default.
- NCIT_C47733 NCIT_NHC0 "C47733" @default.
- NCIT_C47733 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47733 NCIT_P108 "Sulconazole Nitrate" @default.
- NCIT_C47733 NCIT_P207 "C0144004" @default.
- NCIT_C47733 NCIT_P210 "61318-91-0" @default.
- NCIT_C47733 NCIT_P319 "1T89100D5U" @default.
- NCIT_C47733 NCIT_P322 "FDA" @default.
- NCIT_C47733 NCIT_P350 "C18H15Cl3N2S.HNO3" @default.
- NCIT_C47733 NCIT_P366 "Sulconazole_Nitrate" @default.
- NCIT_C47733 normalizedInformationContent "100" @default.
- NCIT_C47733 referenceCount "1" @default.
- NCIT_C47733 hasExactSynonym "(+-)-1-(2,4-Dichloro-beta-((4-chlorobenzyl)thio)phenethyl)imidazole Nitrate" @default.
- NCIT_C47733 hasExactSynonym "1H-Imidazole, 1-(2-(((4-chlorophenyl)methyl)thio)-2-(2,4-dichlorophenyl)ethyl)-, Mononitrate,(+-)-" @default.
- NCIT_C47733 hasExactSynonym "Exelderm" @default.
- NCIT_C47733 hasExactSynonym "SULCONAZOLE NITRATE" @default.
- NCIT_C47733 hasExactSynonym "Sulconazole Nitrate" @default.
- NCIT_C47733 inSubset NCIT_C63923 @default.
- NCIT_C47733 type Class @default.
- NCIT_C47733 isDefinedBy ncit.owl @default.
- NCIT_C47733 label "Sulconazole Nitrate" @default.
- NCIT_C47733 subClassOf NCIT_C1908 @default.
- NCIT_C47733 subClassOf NCIT_C1909 @default.
- NCIT_C47733 subClassOf NCIT_C254 @default.
- NCIT_C47733 subClassOf NCIT_C47733 @default.
- NCIT_C47733 subClassOf NCIT_C514 @default.