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- NCIT_C47735 IAO_0000115 "A broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial properties. Sulfadoxine competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid. This leads to an inhibition of parasitic folic acid synthesis and de novo synthesis of purines and pyrimidines, ultimately resulting in cell growth arrest and cell death." @default.
- NCIT_C47735 NCIT_NHC0 "C47735" @default.
- NCIT_C47735 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47735 NCIT_P108 "Sulfadoxine" @default.
- NCIT_C47735 NCIT_P207 "C0038679" @default.
- NCIT_C47735 NCIT_P210 "2447-57-6" @default.
- NCIT_C47735 NCIT_P319 "88463U4SM5" @default.
- NCIT_C47735 NCIT_P322 "FDA" @default.
- NCIT_C47735 NCIT_P350 "C12H14N4O4S" @default.
- NCIT_C47735 NCIT_P366 "Sulfadoxine" @default.
- NCIT_C47735 NCIT_P368 "CHEBI:9329" @default.
- NCIT_C47735 normalizedInformationContent "100" @default.
- NCIT_C47735 referenceCount "1" @default.
- NCIT_C47735 hasExactSynonym "Benzenesulfonamide, 4-amino-N-(5,6-dimethoxy-4-pyrimidinyl)-" @default.
- NCIT_C47735 hasExactSynonym "N'-(5,6-Dimethoxy-4-pyrimidyl)sulfanilamide" @default.
- NCIT_C47735 hasExactSynonym "SULFADOXINE" @default.
- NCIT_C47735 hasExactSynonym "Sulfadoxine" @default.
- NCIT_C47735 inSubset NCIT_C63923 @default.
- NCIT_C47735 type Class @default.
- NCIT_C47735 isDefinedBy ncit.owl @default.
- NCIT_C47735 label "Sulfadoxine" @default.
- NCIT_C47735 subClassOf NCIT_C1908 @default.
- NCIT_C47735 subClassOf NCIT_C1909 @default.
- NCIT_C47735 subClassOf NCIT_C254 @default.
- NCIT_C47735 subClassOf NCIT_C271 @default.
- NCIT_C47735 subClassOf NCIT_C276 @default.
- NCIT_C47735 subClassOf NCIT_C277 @default.
- NCIT_C47735 subClassOf NCIT_C47735 @default.