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- NCIT_C47743 IAO_0000115 "A carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of cGMP, which is found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. Inhibition of cGMP degradation by tadalafil results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, and, so, prolonged penile erection." @default.
- NCIT_C47743 NCIT_NHC0 "C47743" @default.
- NCIT_C47743 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47743 NCIT_P107 "Tadalafil" @default.
- NCIT_C47743 NCIT_P108 "Tadalafil" @default.
- NCIT_C47743 NCIT_P207 "C1176316" @default.
- NCIT_C47743 NCIT_P210 "171596-29-5" @default.
- NCIT_C47743 NCIT_P302 "Benign Prostatic Hyperplasia" @default.
- NCIT_C47743 NCIT_P319 "742SXX0ICT" @default.
- NCIT_C47743 NCIT_P322 "CTRP" @default.
- NCIT_C47743 NCIT_P322 "FDA" @default.
- NCIT_C47743 NCIT_P325 "A drug used to treat erectile dysfunction. It is also being studied in the treatment of sexual problems in patients treated with radiation or surgery for prostate cancer. Tadalafil blocks the action of a certain enzyme, which can result in increased blood flow to the penis, causing an erection. It is a type of cGMP phosphodiesterase type 5 (PDE5) inhibitor." @default.
- NCIT_C47743 NCIT_P329 "462366" @default.
- NCIT_C47743 NCIT_P330 "462366" @default.
- NCIT_C47743 NCIT_P350 "C22H19N3O4" @default.
- NCIT_C47743 NCIT_P366 "Tadalafil" @default.
- NCIT_C47743 NCIT_P399 "462366" @default.
- NCIT_C47743 normalizedInformationContent "100" @default.
- NCIT_C47743 referenceCount "1" @default.
- NCIT_C47743 hasExactSynonym "(6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione" @default.
- NCIT_C47743 hasExactSynonym "Cialis" @default.
- NCIT_C47743 hasExactSynonym "Ic351" @default.
- NCIT_C47743 hasExactSynonym "TADALAFIL" @default.
- NCIT_C47743 hasExactSynonym "Tadalafil" @default.
- NCIT_C47743 hasExactSynonym "tadalafil" @default.
- NCIT_C47743 inSubset NCIT_C116977 @default.
- NCIT_C47743 inSubset NCIT_C116978 @default.
- NCIT_C47743 inSubset NCIT_C176424 @default.
- NCIT_C47743 inSubset NCIT_C63923 @default.
- NCIT_C47743 type Class @default.
- NCIT_C47743 isDefinedBy ncit.owl @default.
- NCIT_C47743 label "Tadalafil" @default.
- NCIT_C47743 subClassOf NCIT_C1908 @default.
- NCIT_C47743 subClassOf NCIT_C1909 @default.
- NCIT_C47743 subClassOf NCIT_C2127 @default.
- NCIT_C47743 subClassOf NCIT_C471 @default.
- NCIT_C47743 subClassOf NCIT_C47743 @default.
- NCIT_C47743 subClassOf NCIT_C744 @default.