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- NCIT_C47748 IAO_0000115 "The sulfate salt form of terbutaline, an ethanolamine derivative with bronchodilating and tocolytic properties. Terbutaline sulfate selectively binds to and activates beta-2 adrenergic receptors, leading to intracellular adenyl cyclase activation via a trimeric G protein and subsequent increase in cyclic cAMP production. Increased cAMP levels result in relaxation of bronchial and vascular smooth muscle mediated through the activation of protein kinase A (PKA), which phosphorylates proteins in control of muscle tone. cAMP also inhibits calcium ion release from intracellular stores, reduces calcium entry into cells and induces the sequestration of intracellular calcium all of which aids the relaxation of airway muscles. Terbutaline sulfate also increases mucociliary clearance and reduces release of inflammatory cell mediators." @default.
- NCIT_C47748 NCIT_A6 NCIT_C61965 @default.
- NCIT_C47748 NCIT_NHC0 "C47748" @default.
- NCIT_C47748 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47748 NCIT_P108 "Terbutaline Sulfate" @default.
- NCIT_C47748 NCIT_P207 "C0039543" @default.
- NCIT_C47748 NCIT_P210 "23031-32-5" @default.
- NCIT_C47748 NCIT_P319 "576PU70Y8E" @default.
- NCIT_C47748 NCIT_P322 "FDA" @default.
- NCIT_C47748 NCIT_P350 "2C12H19NO3.H2SO4" @default.
- NCIT_C47748 NCIT_P366 "Terbutaline_Sulfate" @default.
- NCIT_C47748 NCIT_P368 "CHEBI:9450" @default.
- NCIT_C47748 normalizedInformationContent "100" @default.
- NCIT_C47748 referenceCount "1" @default.
- NCIT_C47748 hasExactSynonym "(+-)-alpha-((tert-Butylamino)methyl)-3,5-dihydroxybenzyl Alcohol Sulfate(2:1)(salt)" @default.
- NCIT_C47748 hasExactSynonym "1,3-Benzenediol, 5-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-, Sulfate(2:1)(salt)" @default.
- NCIT_C47748 hasExactSynonym "1-(3,5-Dihydroxyphenyl)-2-tert-butylaminoethanol Sulphate" @default.
- NCIT_C47748 hasExactSynonym "Brethaire" @default.
- NCIT_C47748 hasExactSynonym "Brethancer" @default.
- NCIT_C47748 hasExactSynonym "Bretine" @default.
- NCIT_C47748 hasExactSynonym "Bricanyl" @default.
- NCIT_C47748 hasExactSynonym "TERBUTALINE SULFATE" @default.
- NCIT_C47748 hasExactSynonym "Terbutaline Sulfate" @default.
- NCIT_C47748 inSubset NCIT_C63923 @default.
- NCIT_C47748 type Class @default.
- NCIT_C47748 isDefinedBy ncit.owl @default.
- NCIT_C47748 label "Terbutaline Sulfate" @default.
- NCIT_C47748 subClassOf NCIT_C1908 @default.
- NCIT_C47748 subClassOf NCIT_C1909 @default.
- NCIT_C47748 subClassOf NCIT_C29712 @default.
- NCIT_C47748 subClassOf NCIT_C29747 @default.
- NCIT_C47748 subClassOf NCIT_C319 @default.
- NCIT_C47748 subClassOf NCIT_C47748 @default.
- NCIT_C47748 subClassOf NCIT_C48149 @default.
- NCIT_C47748 subClassOf NCIT_C78272 @default.
- NCIT_C47748 subClassOf NCIT_C78273 @default.
- NCIT_C47748 subClassOf NCIT_C87053 @default.