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- NCIT_C47752 IAO_0000115 "A thioxanthene derivative and a dopamine antagonist with antipsychotic property. Thiothixene blocks postsynaptic dopamine receptors in the mesolimbic system and medullary chemoreceptor trigger zone, thereby decreasing dopamine activity leading to decreased stimulation of the vomiting center and psychotic effects, such as hallucinations and delusions. In addition, this agent blocks the D2 somatodendritic autoreceptor, thereby increasing dopamine turnover. Thiothixene possesses weak affinity for the histamine H1 and alpha-adrenergic receptors." @default.
- NCIT_C47752 NCIT_A5 NCIT_C47753 @default.
- NCIT_C47752 NCIT_NHC0 "C47752" @default.
- NCIT_C47752 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47752 NCIT_P108 "Thiothixene" @default.
- NCIT_C47752 NCIT_P175 "108165" @default.
- NCIT_C47752 NCIT_P207 "C0039955" @default.
- NCIT_C47752 NCIT_P210 "3313-26-6" @default.
- NCIT_C47752 NCIT_P319 "7318FJ13YJ" @default.
- NCIT_C47752 NCIT_P322 "FDA" @default.
- NCIT_C47752 NCIT_P350 "C23H29N3O2S2" @default.
- NCIT_C47752 NCIT_P366 "Thiothixene" @default.
- NCIT_C47752 normalizedInformationContent "100" @default.
- NCIT_C47752 referenceCount "1" @default.
- NCIT_C47752 hasExactSynonym "9H-Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-" @default.
- NCIT_C47752 hasExactSynonym "N,N-Dimethyl-9-(3-(4-methylpiperazin-1-yl)propylidene)-9H-thioxanthene-2-sulphonamide" @default.
- NCIT_C47752 hasExactSynonym "Navaron" @default.
- NCIT_C47752 hasExactSynonym "Orbinamon" @default.
- NCIT_C47752 hasExactSynonym "P-4657 B" @default.
- NCIT_C47752 hasExactSynonym "THIOTHIXENE" @default.
- NCIT_C47752 hasExactSynonym "Thiothixene" @default.
- NCIT_C47752 hasExactSynonym "Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-" @default.
- NCIT_C47752 inSubset NCIT_C63923 @default.
- NCIT_C47752 type Class @default.
- NCIT_C47752 isDefinedBy ncit.owl @default.
- NCIT_C47752 label "Thiothixene" @default.
- NCIT_C47752 subClassOf NCIT_C1908 @default.
- NCIT_C47752 subClassOf NCIT_C1909 @default.
- NCIT_C47752 subClassOf NCIT_C29710 @default.
- NCIT_C47752 subClassOf NCIT_C47752 @default.
- NCIT_C47752 subClassOf NCIT_C78272 @default.