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- NCIT_C47755 IAO_0000115 "The hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. Tiagabine hydrochloride inhibits the gamma-aminobutyric acid (GABA) transporter type 1 (GAT1), which is predominantly localized in presynaptic terminals of neurons thereby preventing the reuptake of GABA by the presynaptic endings. Consequently, this increases the level of available GABA within the synaptic cleft, thereby resulting in prolongation of its inhibitory actions. Tiagabine is effective against maximum electroshock seizures and both limbic and generalized tonic-clonic seizures." @default.
- NCIT_C47755 NCIT_A6 NCIT_C66602 @default.
- NCIT_C47755 NCIT_NHC0 "C47755" @default.
- NCIT_C47755 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47755 NCIT_P108 "Tiagabine Hydrochloride" @default.
- NCIT_C47755 NCIT_P207 "C0772200" @default.
- NCIT_C47755 NCIT_P210 "145821-59-6" @default.
- NCIT_C47755 NCIT_P319 "DQH6T6D8OY" @default.
- NCIT_C47755 NCIT_P322 "FDA" @default.
- NCIT_C47755 NCIT_P350 "C20H25NO2S2.HCl" @default.
- NCIT_C47755 NCIT_P366 "Tiagabine_Hydrochloride" @default.
- NCIT_C47755 normalizedInformationContent "100" @default.
- NCIT_C47755 referenceCount "1" @default.
- NCIT_C47755 hasExactSynonym "(-)-(R)-1-(4,4-Bis(3-methyl-2-thienyl)-3-butenyl)nipecotic Acid, Hydrochloride" @default.
- NCIT_C47755 hasExactSynonym "3-Piperidinecarboxylic Acid, 1-(4,4-bis(3-methyl-2-thienyl)-3-buten-yl)-, Hydrochloride,(R)-" @default.
- NCIT_C47755 hasExactSynonym "Gabitril" @default.
- NCIT_C47755 hasExactSynonym "NNC-05-0328" @default.
- NCIT_C47755 hasExactSynonym "TIAGABINE HYDROCHLORIDE" @default.
- NCIT_C47755 hasExactSynonym "Tiagabine Hydrochloride" @default.
- NCIT_C47755 inSubset NCIT_C63923 @default.
- NCIT_C47755 type Class @default.
- NCIT_C47755 isDefinedBy ncit.owl @default.
- NCIT_C47755 label "Tiagabine Hydrochloride" @default.
- NCIT_C47755 subClassOf NCIT_C1908 @default.
- NCIT_C47755 subClassOf NCIT_C1909 @default.
- NCIT_C47755 subClassOf NCIT_C264 @default.
- NCIT_C47755 subClassOf NCIT_C47755 @default.
- NCIT_C47755 subClassOf NCIT_C78272 @default.