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- NCIT_C47761 IAO_0000115 "The hydrochloride salt form of tocainide, a primary amine analog of lidocaine exhibiting class 1b antiarrhythmic property. Tocainide hydrochloride stabilizes the neuronal membrane by reversibly binding to and blocking open and inactivated voltage-gated sodium channels. This inhibits the inward sodium current required for the initiation and conduction of impulses and reduces the excitability of myocardial cells. This agent reduces the rate of rise and amplitude, and shortens the action-potential duration (APD) in both the Purkinje and muscle fibers. Tocainide also shortens the effective refractory period (ERP) of Purkinje fibers resulting in an increased the ERP/APD ratio. Overall these effects lead to the slowing of nerve impulses and stabilization of the heartbeat." @default.
- NCIT_C47761 NCIT_A6 NCIT_C66607 @default.
- NCIT_C47761 NCIT_NHC0 "C47761" @default.
- NCIT_C47761 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47761 NCIT_P108 "Tocainide Hydrochloride" @default.
- NCIT_C47761 NCIT_P175 "130820" @default.
- NCIT_C47761 NCIT_P175 "169863" @default.
- NCIT_C47761 NCIT_P175 "62103" @default.
- NCIT_C47761 NCIT_P207 "C0886765" @default.
- NCIT_C47761 NCIT_P210 "35891-93-1" @default.
- NCIT_C47761 NCIT_P210 "71395-14-7" @default.
- NCIT_C47761 NCIT_P319 "2K7I38CKN5" @default.
- NCIT_C47761 NCIT_P322 "FDA" @default.
- NCIT_C47761 NCIT_P350 "C11H16N2O.HCl" @default.
- NCIT_C47761 NCIT_P366 "Tocainide_Hydrochloride" @default.
- NCIT_C47761 normalizedInformationContent "100" @default.
- NCIT_C47761 referenceCount "1" @default.
- NCIT_C47761 hasExactSynonym "Propanamide, 2-amino-N-(2,6-dimethylphenyl)-, Monohydrochloride" @default.
- NCIT_C47761 hasExactSynonym "TOCAINIDE HYDROCHLORIDE" @default.
- NCIT_C47761 hasExactSynonym "Taquidil" @default.
- NCIT_C47761 hasExactSynonym "Tocainide Hydrochloride" @default.
- NCIT_C47761 hasExactSynonym "Tonocard" @default.
- NCIT_C47761 hasExactSynonym "Xylotocan" @default.
- NCIT_C47761 inSubset NCIT_C63923 @default.
- NCIT_C47761 type Class @default.
- NCIT_C47761 isDefinedBy ncit.owl @default.
- NCIT_C47761 label "Tocainide Hydrochloride" @default.
- NCIT_C47761 subClassOf NCIT_C1908 @default.
- NCIT_C47761 subClassOf NCIT_C1909 @default.
- NCIT_C47761 subClassOf NCIT_C47761 @default.
- NCIT_C47761 subClassOf NCIT_C47793 @default.
- NCIT_C47761 subClassOf NCIT_C78274 @default.
- NCIT_C47761 subClassOf NCIT_C93038 @default.