Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C47764> ?p ?o ?g. }
Showing items 1 to 30 of
30
with 100 items per page.
- NCIT_C47764 IAO_0000115 "A sulfamate-substituted monosaccharide with anticonvulsant property. Although the mechanism of action has not been fully elucidated, topiramate antagonizes kainate/AMPA subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (GABA) activity and thereby attenuating GABAnergic inhibitory transmission." @default.
- NCIT_C47764 NCIT_NHC0 "C47764" @default.
- NCIT_C47764 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47764 NCIT_P108 "Topiramate" @default.
- NCIT_C47764 NCIT_P207 "C0076829" @default.
- NCIT_C47764 NCIT_P210 "97240-79-4" @default.
- NCIT_C47764 NCIT_P319 "0H73WJJ391" @default.
- NCIT_C47764 NCIT_P322 "FDA" @default.
- NCIT_C47764 NCIT_P329 "670650" @default.
- NCIT_C47764 NCIT_P330 "670650" @default.
- NCIT_C47764 NCIT_P350 "C12H21NO8S" @default.
- NCIT_C47764 NCIT_P366 "Topiramate" @default.
- NCIT_C47764 NCIT_P368 "CHEBI:63631" @default.
- NCIT_C47764 NCIT_P399 "670650" @default.
- NCIT_C47764 normalizedInformationContent "100" @default.
- NCIT_C47764 referenceCount "1" @default.
- NCIT_C47764 hasExactSynonym "TOPIRAMATE" @default.
- NCIT_C47764 hasExactSynonym "Topamax" @default.
- NCIT_C47764 hasExactSynonym "Topiramate" @default.
- NCIT_C47764 hasExactSynonym "beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, Sulfamate" @default.
- NCIT_C47764 inSubset NCIT_C176424 @default.
- NCIT_C47764 inSubset NCIT_C63923 @default.
- NCIT_C47764 type Class @default.
- NCIT_C47764 isDefinedBy ncit.owl @default.
- NCIT_C47764 label "Topiramate" @default.
- NCIT_C47764 subClassOf NCIT_C1908 @default.
- NCIT_C47764 subClassOf NCIT_C1909 @default.
- NCIT_C47764 subClassOf NCIT_C264 @default.
- NCIT_C47764 subClassOf NCIT_C47764 @default.
- NCIT_C47764 subClassOf NCIT_C78272 @default.