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- NCIT_C47772 IAO_0000115 "A dione-type anticonvulsant with antiepileptic activity. Trimethadione reduces T-type calcium currents in thalamic neurons, thereby stabilizing neuronal membranes, raising the threshold for repetitive activities in the thalamus and inhibiting corticothalamic transmission. This decreases the abnormal thalamocortical rhythmicity, which is thought to underlie the paroxysmal three-cycle-per-second spike-and-wave pattern seen with absence (petit mal) seizures." @default.
- NCIT_C47772 NCIT_NHC0 "C47772" @default.
- NCIT_C47772 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47772 NCIT_P108 "Trimethadione" @default.
- NCIT_C47772 NCIT_P175 "15799" @default.
- NCIT_C47772 NCIT_P207 "C0041038" @default.
- NCIT_C47772 NCIT_P210 "127-48-0" @default.
- NCIT_C47772 NCIT_P319 "R7GV3H6FQ4" @default.
- NCIT_C47772 NCIT_P322 "FDA" @default.
- NCIT_C47772 NCIT_P350 "C6H9NO3" @default.
- NCIT_C47772 NCIT_P366 "Trimethadione" @default.
- NCIT_C47772 normalizedInformationContent "100" @default.
- NCIT_C47772 referenceCount "1" @default.
- NCIT_C47772 hasExactSynonym "2,4-Oxazolidinedione, 3,5,5-trimethyl-" @default.
- NCIT_C47772 hasExactSynonym "TRIMETHADIONE" @default.
- NCIT_C47772 hasExactSynonym "Tridione" @default.
- NCIT_C47772 hasExactSynonym "Trimethadione" @default.
- NCIT_C47772 inSubset NCIT_C63923 @default.
- NCIT_C47772 type Class @default.
- NCIT_C47772 isDefinedBy ncit.owl @default.
- NCIT_C47772 label "Trimethadione" @default.
- NCIT_C47772 subClassOf NCIT_C1908 @default.
- NCIT_C47772 subClassOf NCIT_C1909 @default.
- NCIT_C47772 subClassOf NCIT_C264 @default.
- NCIT_C47772 subClassOf NCIT_C47772 @default.
- NCIT_C47772 subClassOf NCIT_C78272 @default.