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- NCIT_C47788 IAO_0000115 "A benzothiazolylpiperazine derivative and an atypical antipsychotic agent with an antischizophrenic property. Ziprasidone functions as an antagonist at the dopamine D2 and serotonin 5-HT2A and 5-HT1D receptors, and as an agonist at the 5-HT1A receptor. Ziprasidone also inhibits the synaptic reuptake of serotonin and norepinephrine. The mechanism of action by which ziprasidone exerts its antischizophrenic effect is unknown but is potentially mediated through a combination of dopamine D2 and serotonin 5-HT2 antagonism. This agent also has antagonistic activity against histamine H1 and alpha-1-adrenergic receptors." @default.
- NCIT_C47788 NCIT_A5 NCIT_C48031 @default.
- NCIT_C47788 NCIT_A5 NCIT_C48032 @default.
- NCIT_C47788 NCIT_NHC0 "C47788" @default.
- NCIT_C47788 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47788 NCIT_P108 "Ziprasidone" @default.
- NCIT_C47788 NCIT_P207 "C0380393" @default.
- NCIT_C47788 NCIT_P210 "146939-27-7" @default.
- NCIT_C47788 NCIT_P319 "6UKA5VEJ6X" @default.
- NCIT_C47788 NCIT_P322 "FDA" @default.
- NCIT_C47788 NCIT_P350 "C21H21ClN4OS" @default.
- NCIT_C47788 NCIT_P366 "Ziprasidone" @default.
- NCIT_C47788 NCIT_P368 "CHEBI:10119" @default.
- NCIT_C47788 normalizedInformationContent "100" @default.
- NCIT_C47788 referenceCount "1" @default.
- NCIT_C47788 hasExactSynonym "2H-Indol-2-one, 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-" @default.
- NCIT_C47788 hasExactSynonym "ZIPRASIDONE" @default.
- NCIT_C47788 hasExactSynonym "Zeldox" @default.
- NCIT_C47788 hasExactSynonym "Ziprasidone" @default.
- NCIT_C47788 inSubset NCIT_C63923 @default.
- NCIT_C47788 type Class @default.
- NCIT_C47788 isDefinedBy ncit.owl @default.
- NCIT_C47788 label "Ziprasidone" @default.
- NCIT_C47788 subClassOf NCIT_C1908 @default.
- NCIT_C47788 subClassOf NCIT_C1909 @default.
- NCIT_C47788 subClassOf NCIT_C29710 @default.
- NCIT_C47788 subClassOf NCIT_C47788 @default.
- NCIT_C47788 subClassOf NCIT_C78272 @default.