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- NCIT_C479 IAO_0000115 "A synthetic molecule combining estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects. (NCI04)" @default.
- NCIT_C479 NCIT_A32 NCIT_C1909 @default.
- NCIT_C479 NCIT_NHC0 "C479" @default.
- NCIT_C479 NCIT_P106 "Organic Chemical" @default.
- NCIT_C479 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C479 NCIT_P108 "Estramustine" @default.
- NCIT_C479 NCIT_P175 "89201" @default.
- NCIT_C479 NCIT_P207 "C0014921" @default.
- NCIT_C479 NCIT_P210 "2998-57-4" @default.
- NCIT_C479 NCIT_P302 "Prostate Neoplasm" @default.
- NCIT_C479 NCIT_P319 "35LT29625A" @default.
- NCIT_C479 NCIT_P322 "FDA" @default.
- NCIT_C479 NCIT_P322 "GDC" @default.
- NCIT_C479 NCIT_P325 "A combination of the hormone estradiol (an estrogen) and nitrogen mustard (an anticancer drug). Used in the palliative therapy of prostate cancer." @default.
- NCIT_C479 NCIT_P350 "C23H31Cl2NO3" @default.
- NCIT_C479 NCIT_P366 "Estramustine" @default.
- NCIT_C479 NCIT_P368 "CHEBI:4868" @default.
- NCIT_C479 NCIT_P375 "Estramustine" @default.
- NCIT_C479 NCIT_R124 NCIT_C17828 @default.
- NCIT_C479 NCIT_R124 NCIT_C20480 @default.
- NCIT_C479 NCIT_R124 NCIT_C40795 @default.
- NCIT_C479 NCIT_R124 NCIT_C40798 @default.
- NCIT_C479 normalizedInformationContent "77.718057547374755" @default.
- NCIT_C479 referenceCount "29" @default.
- NCIT_C479 hasExactSynonym "17beta-(estra-1,3,5(10)-triene-3,17-diol 3-(bis(2-chloroethyl)carbamate))" @default.
- NCIT_C479 hasExactSynonym "ESTRAMUSTINE" @default.
- NCIT_C479 hasExactSynonym "Estradiol 3-[bis(2-chloroethyl)carbamate]" @default.
- NCIT_C479 hasExactSynonym "Estramustine" @default.
- NCIT_C479 hasExactSynonym "Leo 275" @default.
- NCIT_C479 hasExactSynonym "RO 21-8837" @default.
- NCIT_C479 hasExactSynonym "estra-1,3,5(10)triene-317beta-diol 3-[N,N-bis-(2-chloroethyl)carbamate]" @default.
- NCIT_C479 hasExactSynonym "estradiol 3-bis(2-chloroethyl)carbamate" @default.
- NCIT_C479 hasExactSynonym "estramustine" @default.
- NCIT_C479 inSubset NCIT_C128784 @default.
- NCIT_C479 inSubset NCIT_C157711 @default.
- NCIT_C479 inSubset NCIT_C157712 @default.
- NCIT_C479 inSubset NCIT_C177537 @default.
- NCIT_C479 inSubset NCIT_C63923 @default.
- NCIT_C479 type Class @default.
- NCIT_C479 isDefinedBy ncit.owl @default.
- NCIT_C479 label "Estramustine" @default.
- NCIT_C479 subClassOf NCIT_C1590 @default.
- NCIT_C479 subClassOf NCIT_C186664 @default.
- NCIT_C479 subClassOf NCIT_C1908 @default.
- NCIT_C479 subClassOf NCIT_C1909 @default.
- NCIT_C479 subClassOf NCIT_C2114 @default.
- NCIT_C479 subClassOf NCIT_C25974 @default.
- NCIT_C479 subClassOf NCIT_C273 @default.
- NCIT_C479 subClassOf NCIT_C274 @default.
- NCIT_C479 subClassOf NCIT_C2842 @default.
- NCIT_C479 subClassOf NCIT_C479 @default.
- NCIT_C479 subClassOf NCIT_C697 @default.