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- NCIT_C47966 IAO_0000115 "The sodium salt form of cefamandole formyl ester. Cefamandole nafate is a pro-drug that is hydrolyzed by plasma esterases to produce cefamandole, a semi-synthetic beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. Cefamandole binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis." @default.
- NCIT_C47966 NCIT_NHC0 "C47966" @default.
- NCIT_C47966 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47966 NCIT_P108 "Cefamandole Nafate" @default.
- NCIT_C47966 NCIT_P175 "299588" @default.
- NCIT_C47966 NCIT_P207 "C0054995" @default.
- NCIT_C47966 NCIT_P210 "42540-40-9" @default.
- NCIT_C47966 NCIT_P319 "8HDO7941DO" @default.
- NCIT_C47966 NCIT_P322 "FDA" @default.
- NCIT_C47966 NCIT_P350 "C19H17N6O6S2.Na" @default.
- NCIT_C47966 NCIT_P366 "Cefamandole_Nafate" @default.
- NCIT_C47966 NCIT_P368 "CHEBI:3481" @default.
- NCIT_C47966 normalizedInformationContent "100" @default.
- NCIT_C47966 referenceCount "1" @default.
- NCIT_C47966 hasExactSynonym "Bergacef" @default.
- NCIT_C47966 hasExactSynonym "CEFAMANDOLE NAFATE" @default.
- NCIT_C47966 hasExactSynonym "Cedol" @default.
- NCIT_C47966 hasExactSynonym "Cefam" @default.
- NCIT_C47966 hasExactSynonym "Cefamandole Nafate" @default.
- NCIT_C47966 hasExactSynonym "Lilly 106223" @default.
- NCIT_C47966 hasExactSynonym "Mandol" @default.
- NCIT_C47966 hasExactSynonym "Mandolsan" @default.
- NCIT_C47966 hasExactSynonym "O-Formylcefamandole Sodium" @default.
- NCIT_C47966 inSubset NCIT_C63923 @default.
- NCIT_C47966 type Class @default.
- NCIT_C47966 isDefinedBy ncit.owl @default.
- NCIT_C47966 label "Cefamandole Nafate" @default.
- NCIT_C47966 subClassOf NCIT_C1908 @default.
- NCIT_C47966 subClassOf NCIT_C1909 @default.
- NCIT_C47966 subClassOf NCIT_C254 @default.
- NCIT_C47966 subClassOf NCIT_C258 @default.
- NCIT_C47966 subClassOf NCIT_C260 @default.
- NCIT_C47966 subClassOf NCIT_C357 @default.
- NCIT_C47966 subClassOf NCIT_C47966 @default.