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- NCIT_C48000 IAO_0000115 "The hydrochloride salt form of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics. Lidocaine interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+. This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation. Lidocaine hydrochloride also exhibits class IB antiarrhythmic effects. The agent decreases the flow of sodium ions into myocardial tissue, especially on the Purkinje network, during phase 0 of the action potential, thereby decreasing depolarization, automaticity and excitability." @default.
- NCIT_C48000 NCIT_A6 NCIT_C614 @default.
- NCIT_C48000 NCIT_NHC0 "C48000" @default.
- NCIT_C48000 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C48000 NCIT_P107 "Lidocaine Hydrochloride" @default.
- NCIT_C48000 NCIT_P108 "Lidocaine Hydrochloride" @default.
- NCIT_C48000 NCIT_P207 "C0546869" @default.
- NCIT_C48000 NCIT_P210 "6108-05-0" @default.
- NCIT_C48000 NCIT_P319 "V13007Z41A" @default.
- NCIT_C48000 NCIT_P322 "CTRP" @default.
- NCIT_C48000 NCIT_P322 "FDA" @default.
- NCIT_C48000 NCIT_P329 "39607" @default.
- NCIT_C48000 NCIT_P330 "39607" @default.
- NCIT_C48000 NCIT_P350 "C14H22N2O.HCl.H2O" @default.
- NCIT_C48000 NCIT_P366 "Lidocaine_Hydrochloride" @default.
- NCIT_C48000 NCIT_P368 "CHEBI:60791" @default.
- NCIT_C48000 NCIT_P399 "39607" @default.
- NCIT_C48000 normalizedInformationContent "100" @default.
- NCIT_C48000 referenceCount "1" @default.
- NCIT_C48000 hasExactSynonym "2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide Monohydrochloride" @default.
- NCIT_C48000 hasExactSynonym "LIDOCAINE HYDROCHLORIDE" @default.
- NCIT_C48000 hasExactSynonym "Lidocaine Hydrochloride" @default.
- NCIT_C48000 hasExactSynonym "Xylocaine" @default.
- NCIT_C48000 hasExactSynonym "Xylocitin" @default.
- NCIT_C48000 hasExactSynonym "Xylotox" @default.
- NCIT_C48000 inSubset NCIT_C116977 @default.
- NCIT_C48000 inSubset NCIT_C116978 @default.
- NCIT_C48000 inSubset NCIT_C176424 @default.
- NCIT_C48000 inSubset NCIT_C63923 @default.
- NCIT_C48000 type Class @default.
- NCIT_C48000 isDefinedBy ncit.owl @default.
- NCIT_C48000 label "Lidocaine Hydrochloride" @default.
- NCIT_C48000 subClassOf NCIT_C1908 @default.
- NCIT_C48000 subClassOf NCIT_C1909 @default.
- NCIT_C48000 subClassOf NCIT_C245 @default.
- NCIT_C48000 subClassOf NCIT_C48000 @default.
- NCIT_C48000 subClassOf NCIT_C78272 @default.