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- NCIT_C48002 IAO_0000115 "A bifunctional alkylating agent and phenylalanine derivative of nitrogen mustard. Melphalan hydrochloride is converted into highly reactive ethylenimmonium intermediates that induce covalent guanine N7-N7 intra- and inter-crosslinks and alkylation of adenine N3 of DNA. This agent also alkylates RNA and protein structures. As a result RNA transcription and protein synthesis are inhibited, ultimately leading to cell growth arrest and/or death." @default.
- NCIT_C48002 NCIT_A32 NCIT_C1909 @default.
- NCIT_C48002 NCIT_A6 NCIT_C633 @default.
- NCIT_C48002 NCIT_NHC0 "C48002" @default.
- NCIT_C48002 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C48002 NCIT_P107 "Melphalan Hydrochloride" @default.
- NCIT_C48002 NCIT_P108 "Melphalan Hydrochloride" @default.
- NCIT_C48002 NCIT_P175 "241286" @default.
- NCIT_C48002 NCIT_P207 "C0771055" @default.
- NCIT_C48002 NCIT_P210 "3223-07-2" @default.
- NCIT_C48002 NCIT_P319 "1VXP4V453T" @default.
- NCIT_C48002 NCIT_P322 "CTRP" @default.
- NCIT_C48002 NCIT_P322 "FDA" @default.
- NCIT_C48002 NCIT_P322 "GDC" @default.
- NCIT_C48002 NCIT_P325 "A drug that is used to treat multiple myeloma and ovarian epithelial cancer and is being studied in the treatment of other types of cancer. It belongs to the family of drugs called alkylating agents." @default.
- NCIT_C48002 NCIT_P329 "42973" @default.
- NCIT_C48002 NCIT_P330 "42973" @default.
- NCIT_C48002 NCIT_P350 "C13H18Cl2N2O2.HCl" @default.
- NCIT_C48002 NCIT_P366 "Melphalan_Hydrochloride" @default.
- NCIT_C48002 NCIT_P375 "Melphalan Hydrochloride" @default.
- NCIT_C48002 NCIT_P399 "42973" @default.
- NCIT_C48002 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C48002 referenceCount "2" @default.
- NCIT_C48002 hasExactSynonym "3-(p-(bis(2-chloroethyl)amino)phenyl)-L-Alanine, Hydrochloride" @default.
- NCIT_C48002 hasExactSynonym "Alkeran" @default.
- NCIT_C48002 hasExactSynonym "Alkerana" @default.
- NCIT_C48002 hasExactSynonym "Evomela" @default.
- NCIT_C48002 hasExactSynonym "MELPHALAN HYDROCHLORIDE" @default.
- NCIT_C48002 hasExactSynonym "Melphalan Hydrochloride" @default.
- NCIT_C48002 inSubset NCIT_C116977 @default.
- NCIT_C48002 inSubset NCIT_C116978 @default.
- NCIT_C48002 inSubset NCIT_C128784 @default.
- NCIT_C48002 inSubset NCIT_C157711 @default.
- NCIT_C48002 inSubset NCIT_C157712 @default.
- NCIT_C48002 inSubset NCIT_C176424 @default.
- NCIT_C48002 inSubset NCIT_C177537 @default.
- NCIT_C48002 inSubset NCIT_C63923 @default.
- NCIT_C48002 type Class @default.
- NCIT_C48002 isDefinedBy ncit.owl @default.
- NCIT_C48002 label "Melphalan Hydrochloride" @default.
- NCIT_C48002 subClassOf NCIT_C1590 @default.
- NCIT_C48002 subClassOf NCIT_C186664 @default.
- NCIT_C48002 subClassOf NCIT_C1908 @default.
- NCIT_C48002 subClassOf NCIT_C1909 @default.
- NCIT_C48002 subClassOf NCIT_C2114 @default.
- NCIT_C48002 subClassOf NCIT_C274 @default.
- NCIT_C48002 subClassOf NCIT_C2842 @default.
- NCIT_C48002 subClassOf NCIT_C48002 @default.
- NCIT_C48002 subClassOf NCIT_C697 @default.