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- NCIT_C48014 IAO_0000115 "The sulfate salt form of quinidine, an alkaloid with antimalarial and antiarrhythmic (Class la) properties. Quinidine sulfate exerts its anti-malarial activity by acting primarily as an intra-erythrocytic schizonticide through association with the hemepolymer (hemozoin) in the acidic food vacuole of the parasite thereby preventing further polymerization by heme polymerase enzyme. This results in accumulation of toxic heme and death of the parasite. Quinidine sulfate exerts its antiarrhythmic effects by depressing the flow of sodium ions into cells during phase 0 of the cardiac action potential, thereby slowing the impulse conduction through the atrioventricular (AV) node, reducing the rate of phase 0 depolarization and prolonging the refractory period. Quinidine sulfate also reduces the slope of phase 4 depolarization in Purkinje-fibres resulting in slowed conduction and reduced automaticity in the heart." @default.
- NCIT_C48014 NCIT_A6 NCIT_C793 @default.
- NCIT_C48014 NCIT_NHC0 "C48014" @default.
- NCIT_C48014 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C48014 NCIT_P108 "Quinidine Sulfate" @default.
- NCIT_C48014 NCIT_P175 "10004" @default.
- NCIT_C48014 NCIT_P207 "C0034415" @default.
- NCIT_C48014 NCIT_P210 "6591-63-5" @default.
- NCIT_C48014 NCIT_P319 "J13S2394HE" @default.
- NCIT_C48014 NCIT_P322 "FDA" @default.
- NCIT_C48014 NCIT_P350 "2C20H24N2O2.2H2O.H2SO4" @default.
- NCIT_C48014 NCIT_P366 "Quinidine_Sulfate" @default.
- NCIT_C48014 NCIT_P368 "CHEBI:28482" @default.
- NCIT_C48014 normalizedInformationContent "100" @default.
- NCIT_C48014 referenceCount "1" @default.
- NCIT_C48014 hasExactSynonym "(9S)-6'-Methoxycinchonan-9-ol Sulfate (2:1) (salt)" @default.
- NCIT_C48014 hasExactSynonym "QUINIDINE SULFATE" @default.
- NCIT_C48014 hasExactSynonym "Quinidex" @default.
- NCIT_C48014 hasExactSynonym "Quinidine Sulfate" @default.
- NCIT_C48014 inSubset NCIT_C63923 @default.
- NCIT_C48014 type Class @default.
- NCIT_C48014 isDefinedBy ncit.owl @default.
- NCIT_C48014 label "Quinidine Sulfate" @default.
- NCIT_C48014 subClassOf NCIT_C1908 @default.
- NCIT_C48014 subClassOf NCIT_C1909 @default.
- NCIT_C48014 subClassOf NCIT_C254 @default.
- NCIT_C48014 subClassOf NCIT_C271 @default.
- NCIT_C48014 subClassOf NCIT_C276 @default.
- NCIT_C48014 subClassOf NCIT_C277 @default.
- NCIT_C48014 subClassOf NCIT_C48014 @default.
- NCIT_C48014 subClassOf NCIT_C93038 @default.