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- NCIT_C48032 IAO_0000115 "The mesylate salt form of ziprasidone, a benzothiazolylpiperazine derivative and an atypical antipsychotic agent with an antischizophrenic property. Ziprasidone mesylate functions as an antagonist at the dopamine D2 and serotonin 5-HT2A and 5-HT1D receptors, and as an agonist at the 5-HT1A receptor. Ziprasidone mesylate also inhibits the synaptic reuptake of serotonin and norepinephrine. The mechanism of action by which ziprasidone mesylate exerts its antischizophrenic effect is unknown but is potentially mediated through a combination of dopamine D2 and serotonin 5-HT2 antagonism. This agent also has antagonistic activity against histamine H1 and alpha-1-adrenergic receptors." @default.
- NCIT_C48032 NCIT_A6 NCIT_C47788 @default.
- NCIT_C48032 NCIT_NHC0 "C48032" @default.
- NCIT_C48032 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C48032 NCIT_P108 "Ziprasidone Mesylate" @default.
- NCIT_C48032 NCIT_P207 "C1170754" @default.
- NCIT_C48032 NCIT_P210 "199191-69-0" @default.
- NCIT_C48032 NCIT_P319 "3X6SAX83JZ" @default.
- NCIT_C48032 NCIT_P322 "FDA" @default.
- NCIT_C48032 NCIT_P350 "C21H21ClN4OS.CH4O3S.3H2O" @default.
- NCIT_C48032 NCIT_P366 "Ziprasidone_Mesylate" @default.
- NCIT_C48032 NCIT_P368 "CHEBI:53757" @default.
- NCIT_C48032 normalizedInformationContent "100" @default.
- NCIT_C48032 referenceCount "1" @default.
- NCIT_C48032 hasExactSynonym "Geodon, for Injection" @default.
- NCIT_C48032 hasExactSynonym "ZIPRASIDONE MESYLATE" @default.
- NCIT_C48032 hasExactSynonym "Ziprasidone Mesylate" @default.
- NCIT_C48032 inSubset NCIT_C63923 @default.
- NCIT_C48032 type Class @default.
- NCIT_C48032 isDefinedBy ncit.owl @default.
- NCIT_C48032 label "Ziprasidone Mesylate" @default.
- NCIT_C48032 subClassOf NCIT_C1908 @default.
- NCIT_C48032 subClassOf NCIT_C1909 @default.
- NCIT_C48032 subClassOf NCIT_C29710 @default.
- NCIT_C48032 subClassOf NCIT_C48032 @default.
- NCIT_C48032 subClassOf NCIT_C78272 @default.