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- NCIT_C48382 IAO_0000115 "A synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities. Bardoxolone blocks the synthesis of inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2), two enzymes involved in inflammation and carcinogenesis. This agent also inhibits the interleukin-1 (IL-1)-induced expression of the pro-inflammatory proteins matrix metalloproteinase-1 (MMP-1) and matrix metalloproteinase-13 (MMP-13) and the expression of Bcl-3; Bcl-3 is an IL-1-responsive gene that preferentially contributes to MMP-1 gene expression." @default.
- NCIT_C48382 NCIT_A32 NCIT_C1909 @default.
- NCIT_C48382 NCIT_NHC0 "C48382" @default.
- NCIT_C48382 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C48382 NCIT_P108 "Bardoxolone" @default.
- NCIT_C48382 NCIT_P175 "711193" @default.
- NCIT_C48382 NCIT_P207 "C0762434" @default.
- NCIT_C48382 NCIT_P210 "218600-44-3" @default.
- NCIT_C48382 NCIT_P302 "Antineoplastic and anti-inflammatory" @default.
- NCIT_C48382 NCIT_P319 "7HT68L8941" @default.
- NCIT_C48382 NCIT_P322 "FDA" @default.
- NCIT_C48382 NCIT_P322 "GDC" @default.
- NCIT_C48382 NCIT_P325 "A substance being studied in the treatment of some types of cancer. CDDO may block enzymes involved in inflammation and cancer growth. It is a type of antineoplastic plant product." @default.
- NCIT_C48382 NCIT_P329 "453589" @default.
- NCIT_C48382 NCIT_P330 "453589" @default.
- NCIT_C48382 NCIT_P350 "C31H41NO4" @default.
- NCIT_C48382 NCIT_P366 "CDDO" @default.
- NCIT_C48382 NCIT_P375 "Bardoxolone" @default.
- NCIT_C48382 NCIT_P399 "453589" @default.
- NCIT_C48382 normalizedInformationContent "100" @default.
- NCIT_C48382 referenceCount "1" @default.
- NCIT_C48382 hasExactSynonym "2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid" @default.
- NCIT_C48382 hasExactSynonym "2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic Acid" @default.
- NCIT_C48382 hasExactSynonym "BARDOXOLONE" @default.
- NCIT_C48382 hasExactSynonym "Bardoxolone" @default.
- NCIT_C48382 hasExactSynonym "CDDO" @default.
- NCIT_C48382 hasExactSynonym "Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-" @default.
- NCIT_C48382 hasExactSynonym "RTA 401" @default.
- NCIT_C48382 inSubset NCIT_C128784 @default.
- NCIT_C48382 inSubset NCIT_C157711 @default.
- NCIT_C48382 inSubset NCIT_C157712 @default.
- NCIT_C48382 inSubset NCIT_C176424 @default.
- NCIT_C48382 inSubset NCIT_C177537 @default.
- NCIT_C48382 inSubset NCIT_C63923 @default.
- NCIT_C48382 type Class @default.
- NCIT_C48382 isDefinedBy ncit.owl @default.
- NCIT_C48382 label "Bardoxolone" @default.
- NCIT_C48382 subClassOf NCIT_C1323 @default.
- NCIT_C48382 subClassOf NCIT_C1908 @default.
- NCIT_C48382 subClassOf NCIT_C1909 @default.
- NCIT_C48382 subClassOf NCIT_C2198 @default.
- NCIT_C48382 subClassOf NCIT_C2356 @default.
- NCIT_C48382 subClassOf NCIT_C241 @default.
- NCIT_C48382 subClassOf NCIT_C257 @default.
- NCIT_C48382 subClassOf NCIT_C29574 @default.
- NCIT_C48382 subClassOf NCIT_C471 @default.
- NCIT_C48382 subClassOf NCIT_C48382 @default.
- NCIT_C48382 subClassOf NCIT_C78272 @default.