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- NCIT_C48383 IAO_0000115 "A cytokine-peptide conjugate composed of the cytokine tumor necrosis factor alpha (TNF-alpha) chemically linked to the peptide CNGRC. The peptide moiety CNGRC, a ligand for the membrane-bound metalloprotease CD13, binds to endothelial cells of the angiogenic vasculature that express CD13 (also known as aminopeptidase N); subsequently, the TNF-alpha moiety induces apoptosis in endothelial cells expressing CD13, thereby inhibiting tumor-associated angiogenesis. (NCI05)" @default.
- NCIT_C48383 NCIT_A7 NCIT_C94661 @default.
- NCIT_C48383 NCIT_NHC0 "C48383" @default.
- NCIT_C48383 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C48383 NCIT_P107 "CNGRC Peptide-TNF Alpha Conjugate" @default.
- NCIT_C48383 NCIT_P108 "CNGRC Peptide-TNF Alpha Conjugate" @default.
- NCIT_C48383 NCIT_P207 "C1143119" @default.
- NCIT_C48383 NCIT_P322 "CTRP" @default.
- NCIT_C48383 NCIT_P325 "A substance being studied in the treatment of cancer. It is made by linking tumor necrosis factor (TNF) to a peptide. The peptide binds to tumor blood vessels, and TNF damages them. It is a type of biological response modifier." @default.
- NCIT_C48383 NCIT_P329 "403156" @default.
- NCIT_C48383 NCIT_P330 "403156" @default.
- NCIT_C48383 NCIT_P366 "CNGRC_Peptide-Tumor_Necrosis_Factor_Alpha_Conjugate" @default.
- NCIT_C48383 NCIT_P399 "403156" @default.
- NCIT_C48383 normalizedInformationContent "100" @default.
- NCIT_C48383 referenceCount "1" @default.
- NCIT_C48383 hasExactSynonym "CNGRC Peptide-TNF Alpha Conjugate" @default.
- NCIT_C48383 hasExactSynonym "NGR-TNF" @default.
- NCIT_C48383 hasExactSynonym "NGR-hTNF" @default.
- NCIT_C48383 hasExactSynonym "tumor vasculature-targeted tumor necrosis factor alpha" @default.
- NCIT_C48383 inSubset NCIT_C116977 @default.
- NCIT_C48383 inSubset NCIT_C116978 @default.
- NCIT_C48383 inSubset NCIT_C128784 @default.
- NCIT_C48383 inSubset NCIT_C176424 @default.
- NCIT_C48383 type Class @default.
- NCIT_C48383 isDefinedBy ncit.owl @default.
- NCIT_C48383 label "CNGRC Peptide-TNF Alpha Conjugate" @default.
- NCIT_C48383 subClassOf NCIT_C1742 @default.
- NCIT_C48383 subClassOf NCIT_C1908 @default.
- NCIT_C48383 subClassOf NCIT_C1909 @default.
- NCIT_C48383 subClassOf NCIT_C2143 @default.
- NCIT_C48383 subClassOf NCIT_C274 @default.
- NCIT_C48383 subClassOf NCIT_C48383 @default.