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- NCIT_C48387 IAO_0000115 "A derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties. In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production. (NCI05)" @default.
- NCIT_C48387 NCIT_A32 NCIT_C1909 @default.
- NCIT_C48387 NCIT_A7 NCIT_C102485 @default.
- NCIT_C48387 NCIT_A7 NCIT_C38929 @default.
- NCIT_C48387 NCIT_NHC0 "C48387" @default.
- NCIT_C48387 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C48387 NCIT_P107 "Everolimus" @default.
- NCIT_C48387 NCIT_P108 "Everolimus" @default.
- NCIT_C48387 NCIT_P175 "733504" @default.
- NCIT_C48387 NCIT_P207 "C0541315" @default.
- NCIT_C48387 NCIT_P210 "159351-69-6" @default.
- NCIT_C48387 NCIT_P302 "neuroendocrine tumors (NET) of gastrointestinal (GI), lung or pancreatic origin" @default.
- NCIT_C48387 NCIT_P319 "9HW64Q8G6G" @default.
- NCIT_C48387 NCIT_P322 "CTRP" @default.
- NCIT_C48387 NCIT_P322 "FDA" @default.
- NCIT_C48387 NCIT_P322 "GDC" @default.
- NCIT_C48387 NCIT_P325 "A drug used to treat advanced kidney cancer that did not respond to treatment with certain other anticancer drugs. It is also being studied in the treatment of other types of cancer. Afinitor stops cancer cells from dividing and may block the growth of new blood vessels that tumors need to grow. It also decreases the body's immune responses. It is a type of immunosuppressant and a type of antiangiogenesis agent." @default.
- NCIT_C48387 NCIT_P329 "372905" @default.
- NCIT_C48387 NCIT_P330 "372905" @default.
- NCIT_C48387 NCIT_P350 "C53H83NO14" @default.
- NCIT_C48387 NCIT_P366 "Everolimus" @default.
- NCIT_C48387 NCIT_P375 "Everolimus" @default.
- NCIT_C48387 NCIT_P399 "372905" @default.
- NCIT_C48387 normalizedInformationContent "83.556969816060246" @default.
- NCIT_C48387 referenceCount "12" @default.
- NCIT_C48387 hasExactSynonym "(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.04,9)hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone" @default.
- NCIT_C48387 hasExactSynonym "42-O-(2-Hydroxy)ethyl Rapamycin" @default.
- NCIT_C48387 hasExactSynonym "Afinitor" @default.
- NCIT_C48387 hasExactSynonym "Certican" @default.
- NCIT_C48387 hasExactSynonym "EVEROLIMUS" @default.
- NCIT_C48387 hasExactSynonym "Everolimus" @default.
- NCIT_C48387 hasExactSynonym "RAD 001" @default.
- NCIT_C48387 hasExactSynonym "RAD-001" @default.
- NCIT_C48387 hasExactSynonym "RAD001" @default.
- NCIT_C48387 hasExactSynonym "Votubia" @default.
- NCIT_C48387 hasExactSynonym "Zortress" @default.
- NCIT_C48387 hasExactSynonym "everolimus" @default.
- NCIT_C48387 inSubset NCIT_C116977 @default.
- NCIT_C48387 inSubset NCIT_C116978 @default.
- NCIT_C48387 inSubset NCIT_C128784 @default.
- NCIT_C48387 inSubset NCIT_C157711 @default.
- NCIT_C48387 inSubset NCIT_C157712 @default.
- NCIT_C48387 inSubset NCIT_C176424 @default.
- NCIT_C48387 inSubset NCIT_C177537 @default.
- NCIT_C48387 inSubset NCIT_C63923 @default.
- NCIT_C48387 type Class @default.
- NCIT_C48387 isDefinedBy ncit.owl @default.
- NCIT_C48387 label "Everolimus" @default.
- NCIT_C48387 subClassOf NCIT_C1404 @default.
- NCIT_C48387 subClassOf NCIT_C163758 @default.
- NCIT_C48387 subClassOf NCIT_C1742 @default.
- NCIT_C48387 subClassOf NCIT_C1908 @default.
- NCIT_C48387 subClassOf NCIT_C1909 @default.
- NCIT_C48387 subClassOf NCIT_C2201 @default.
- NCIT_C48387 subClassOf NCIT_C274 @default.
- NCIT_C48387 subClassOf NCIT_C308 @default.
- NCIT_C48387 subClassOf NCIT_C471 @default.
- NCIT_C48387 subClassOf NCIT_C48387 @default.
- NCIT_C48387 subClassOf NCIT_C574 @default.
- NCIT_C48387 subClassOf NCIT_C61074 @default.