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- NCIT_C484 IAO_0000115 "The synthetic form of a naturally occurring estrogen estrone. Estrone diffuses through the cell membrane and binds to and subsequently activates the nuclear estrogen receptor found in the reproductive tract, breast, pituitary, hypothalamus, liver, and bone. The activated hormone-receptor complex gets translocated to the nucleus where it binds to the estrogen response element on the DNA and promotes the transcription of target genes involved in the functioning of the female reproductive system and secondary sex characteristics. Estrone increases the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins, as well as suppresses the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary." @default.
- NCIT_C484 NCIT_A5 NCIT_C1091 @default.
- NCIT_C484 NCIT_A5 NCIT_C61942 @default.
- NCIT_C484 NCIT_NHC0 "C484" @default.
- NCIT_C484 NCIT_P106 "Organic Chemical" @default.
- NCIT_C484 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C484 NCIT_P108 "Therapeutic Estrone" @default.
- NCIT_C484 NCIT_P175 "9699" @default.
- NCIT_C484 NCIT_P208 "CL1773622" @default.
- NCIT_C484 NCIT_P210 "53-16-7" @default.
- NCIT_C484 NCIT_P319 "2DI9HA706A" @default.
- NCIT_C484 NCIT_P322 "FDA" @default.
- NCIT_C484 NCIT_P350 "C18H22O2" @default.
- NCIT_C484 NCIT_P366 "Therapeutic_Estrone" @default.
- NCIT_C484 NCIT_P368 "CHEBI:17263" @default.
- NCIT_C484 normalizedInformationContent "100" @default.
- NCIT_C484 referenceCount "1" @default.
- NCIT_C484 hasExactSynonym "ESTRONE" @default.
- NCIT_C484 hasExactSynonym "Estrone" @default.
- NCIT_C484 hasExactSynonym "Oestrone" @default.
- NCIT_C484 hasExactSynonym "Theelin" @default.
- NCIT_C484 hasExactSynonym "Therapeutic Estrone" @default.
- NCIT_C484 inSubset NCIT_C63923 @default.
- NCIT_C484 type Class @default.
- NCIT_C484 isDefinedBy ncit.owl @default.
- NCIT_C484 label "Therapeutic Estrone" @default.
- NCIT_C484 subClassOf NCIT_C147908 @default.
- NCIT_C484 subClassOf NCIT_C1636 @default.
- NCIT_C484 subClassOf NCIT_C1908 @default.
- NCIT_C484 subClassOf NCIT_C1909 @default.
- NCIT_C484 subClassOf NCIT_C2181 @default.
- NCIT_C484 subClassOf NCIT_C483 @default.
- NCIT_C484 subClassOf NCIT_C484 @default.
- NCIT_C484 subClassOf NCIT_C548 @default.