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- NCIT_C48401 IAO_0000115 "The hydrochloride salt of a small-molecule inhibitor of heat shock protein 90 (HSP90) with antiproliferative and antineoplastic activities. Retaspimycin binds to and inhibits the cytosolic chaperone functions of HSP90, which maintains the stability and functional shape of many oncogenic signaling proteins and may be overexpressed or overactive in tumor cells. Retaspimycin-mediated inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins in susceptible tumor cell populations, which may result in the induction of apoptosis." @default.
- NCIT_C48401 NCIT_A32 NCIT_C1909 @default.
- NCIT_C48401 NCIT_A6 NCIT_C80378 @default.
- NCIT_C48401 NCIT_A7 NCIT_C17766 @default.
- NCIT_C48401 NCIT_NHC0 "C48401" @default.
- NCIT_C48401 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C48401 NCIT_P107 "Retaspimycin Hydrochloride" @default.
- NCIT_C48401 NCIT_P108 "Retaspimycin Hydrochloride" @default.
- NCIT_C48401 NCIT_P207 "C1708447" @default.
- NCIT_C48401 NCIT_P210 "857402-63-2" @default.
- NCIT_C48401 NCIT_P319 "928Q33Q049" @default.
- NCIT_C48401 NCIT_P322 "CTRP" @default.
- NCIT_C48401 NCIT_P322 "FDA" @default.
- NCIT_C48401 NCIT_P322 "GDC" @default.
- NCIT_C48401 NCIT_P329 "437784" @default.
- NCIT_C48401 NCIT_P330 "437784" @default.
- NCIT_C48401 NCIT_P350 "C31H45N3O8.HCl" @default.
- NCIT_C48401 NCIT_P366 "IPI-504" @default.
- NCIT_C48401 NCIT_P375 "Retaspimycin Hydrochloride" @default.
- NCIT_C48401 NCIT_P399 "437784" @default.
- NCIT_C48401 NCIT_R124 NCIT_C17710 @default.
- NCIT_C48401 NCIT_R124 NCIT_C17828 @default.
- NCIT_C48401 NCIT_R124 NCIT_C18219 @default.
- NCIT_C48401 NCIT_R124 NCIT_C19986 @default.
- NCIT_C48401 NCIT_R124 NCIT_C40952 @default.
- NCIT_C48401 NCIT_R124 NCIT_C41571 @default.
- NCIT_C48401 NCIT_R125 NCIT_C17133 @default.
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- NCIT_C48401 NCIT_R125 NCIT_C17828 @default.
- NCIT_C48401 NCIT_R125 NCIT_C18104 @default.
- NCIT_C48401 NCIT_R125 NCIT_C19406 @default.
- NCIT_C48401 NCIT_R125 NCIT_C19536 @default.
- NCIT_C48401 NCIT_R125 NCIT_C19903 @default.
- NCIT_C48401 NCIT_R125 NCIT_C19986 @default.
- NCIT_C48401 NCIT_R125 NCIT_C20480 @default.
- NCIT_C48401 NCIT_R125 NCIT_C21198 @default.
- NCIT_C48401 NCIT_R125 NCIT_C28498 @default.
- NCIT_C48401 NCIT_R125 NCIT_C40673 @default.
- NCIT_C48401 NCIT_R125 NCIT_C40821 @default.
- NCIT_C48401 NCIT_R125 NCIT_C61559 @default.
- NCIT_C48401 NCIT_R146 NCIT_C16672 @default.
- NCIT_C48401 NCIT_R146 NCIT_C17021 @default.
- NCIT_C48401 NCIT_R146 NCIT_C17766 @default.
- NCIT_C48401 NCIT_R146 NCIT_C20130 @default.
- NCIT_C48401 NCIT_R146 NCIT_C26548 @default.
- NCIT_C48401 normalizedInformationContent "100" @default.
- NCIT_C48401 referenceCount "1" @default.
- NCIT_C48401 hasExactSynonym "17-Allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride" @default.
- NCIT_C48401 hasExactSynonym "Geldanamycin, 18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propenylamino)-, monohydrochloride" @default.
- NCIT_C48401 hasExactSynonym "IPI-504" @default.
- NCIT_C48401 hasExactSynonym "RETASPIMYCIN HYDROCHLORIDE" @default.
- NCIT_C48401 hasExactSynonym "Retaspimycin Hydrochloride" @default.
- NCIT_C48401 inSubset NCIT_C116977 @default.
- NCIT_C48401 inSubset NCIT_C116978 @default.
- NCIT_C48401 inSubset NCIT_C128784 @default.
- NCIT_C48401 inSubset NCIT_C157711 @default.
- NCIT_C48401 inSubset NCIT_C157712 @default.
- NCIT_C48401 inSubset NCIT_C176424 @default.
- NCIT_C48401 inSubset NCIT_C177537 @default.
- NCIT_C48401 inSubset NCIT_C63923 @default.
- NCIT_C48401 type Class @default.
- NCIT_C48401 isDefinedBy ncit.owl @default.
- NCIT_C48401 label "Retaspimycin Hydrochloride" @default.
- NCIT_C48401 subClassOf NCIT_C1003 @default.
- NCIT_C48401 subClassOf NCIT_C129824 @default.
- NCIT_C48401 subClassOf NCIT_C186664 @default.
- NCIT_C48401 subClassOf NCIT_C1908 @default.
- NCIT_C48401 subClassOf NCIT_C1909 @default.
- NCIT_C48401 subClassOf NCIT_C2189 @default.
- NCIT_C48401 subClassOf NCIT_C2516 @default.
- NCIT_C48401 subClassOf NCIT_C259 @default.
- NCIT_C48401 subClassOf NCIT_C274 @default.
- NCIT_C48401 subClassOf NCIT_C48401 @default.
- NCIT_C48401 subClassOf NCIT_C74526 @default.