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- NCIT_C48403 IAO_0000115 "A methyl derivative of noroxymorphone with selective, opioid-receptor antagonistic activity. Methylnaltrexone displaces opioids from peripheral opioid receptors in the gastrointestinal tract, the bladder, and the skin, resulting in decreases in opioid-related constipation, urinary retention, and pruritis, respectively. Methylnaltrexone does not cross the blood-brain barrier and does not affect the centrally-mediated analgesic effect of opioids." @default.
- NCIT_C48403 NCIT_A5 NCIT_C80569 @default.
- NCIT_C48403 NCIT_A7 NCIT_C118985 @default.
- NCIT_C48403 NCIT_NHC0 "C48403" @default.
- NCIT_C48403 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C48403 NCIT_P107 "Methylnaltrexone" @default.
- NCIT_C48403 NCIT_P108 "Methylnaltrexone" @default.
- NCIT_C48403 NCIT_P207 "C0066411" @default.
- NCIT_C48403 NCIT_P210 "83387-25-1" @default.
- NCIT_C48403 NCIT_P319 "0RK7M7IABE" @default.
- NCIT_C48403 NCIT_P322 "CTRP" @default.
- NCIT_C48403 NCIT_P322 "FDA" @default.
- NCIT_C48403 NCIT_P325 "The active ingredient in a drug used to relieve certain side effects caused by treatment with opiods (pain killers similar to morphine), such as constipation (hard, dry stools), itching, and low urine flow. Methylnaltrexone binds to opioid receptors outside the brain and may block the side effects of opioid drugs without affecting their ability to relieve pain. Methylnaltrexone is a type of peripheral opioid receptor antagonist." @default.
- NCIT_C48403 NCIT_P329 "437863" @default.
- NCIT_C48403 NCIT_P330 "437863" @default.
- NCIT_C48403 NCIT_P350 "C21H26NO4" @default.
- NCIT_C48403 NCIT_P366 "Methylnaltrexone" @default.
- NCIT_C48403 NCIT_P399 "437863" @default.
- NCIT_C48403 normalizedInformationContent "100" @default.
- NCIT_C48403 referenceCount "1" @default.
- NCIT_C48403 hasExactSynonym "17-(Cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium" @default.
- NCIT_C48403 hasExactSynonym "METHYLNALTREXONE" @default.
- NCIT_C48403 hasExactSynonym "Methylnaltrexone" @default.
- NCIT_C48403 hasExactSynonym "Quaternary Ammonium Naltrexone" @default.
- NCIT_C48403 hasExactSynonym "methylnaltrexone" @default.
- NCIT_C48403 inSubset NCIT_C116977 @default.
- NCIT_C48403 inSubset NCIT_C116978 @default.
- NCIT_C48403 inSubset NCIT_C176424 @default.
- NCIT_C48403 inSubset NCIT_C63923 @default.
- NCIT_C48403 type Class @default.
- NCIT_C48403 isDefinedBy ncit.owl @default.
- NCIT_C48403 label "Methylnaltrexone" @default.
- NCIT_C48403 subClassOf NCIT_C1908 @default.
- NCIT_C48403 subClassOf NCIT_C1909 @default.
- NCIT_C48403 subClassOf NCIT_C48403 @default.
- NCIT_C48403 subClassOf NCIT_C681 @default.
- NCIT_C48403 subClassOf NCIT_C78272 @default.