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- NCIT_C48405 IAO_0000115 "A fully human monoclonal antibody directed against the B-cell surface antigen CD40 with potential antineoplastic activity. Lucatumumab binds to and inhibits CD40, thereby inhibiting CD40 ligand-induced cell proliferation and triggering cell lysis via antibody-dependent cellular cytotoxicity (ADCC) in cells overexpressing CD40. CD40, an integral membrane protein found on the surface of B lymphocytes, is a member of the tumor necrosis factor receptor superfamily and is highly expressed in a number of B-cell malignancies." @default.
- NCIT_C48405 NCIT_A32 NCIT_C1909 @default.
- NCIT_C48405 NCIT_A7 NCIT_C17281 @default.
- NCIT_C48405 NCIT_NHC0 "C48405" @default.
- NCIT_C48405 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C48405 NCIT_P107 "Lucatumumab" @default.
- NCIT_C48405 NCIT_P108 "Lucatumumab" @default.
- NCIT_C48405 NCIT_P207 "C2980061" @default.
- NCIT_C48405 NCIT_P210 "903512-50-5" @default.
- NCIT_C48405 NCIT_P319 "P0EP9VFC4R" @default.
- NCIT_C48405 NCIT_P322 "CTRP" @default.
- NCIT_C48405 NCIT_P322 "FDA" @default.
- NCIT_C48405 NCIT_P322 "GDC" @default.
- NCIT_C48405 NCIT_P329 "432936" @default.
- NCIT_C48405 NCIT_P330 "432936" @default.
- NCIT_C48405 NCIT_P366 "Monoclonal_Antibody_CHIR-12_12" @default.
- NCIT_C48405 NCIT_P375 "Lucatumumab" @default.
- NCIT_C48405 NCIT_P399 "432936" @default.
- NCIT_C48405 NCIT_R124 NCIT_C17710 @default.
- NCIT_C48405 NCIT_R124 NCIT_C17828 @default.
- NCIT_C48405 NCIT_R124 NCIT_C18219 @default.
- NCIT_C48405 NCIT_R124 NCIT_C19986 @default.
- NCIT_C48405 NCIT_R124 NCIT_C40474 @default.
- NCIT_C48405 normalizedInformationContent "100" @default.
- NCIT_C48405 referenceCount "1" @default.
- NCIT_C48405 hasExactSynonym "Anti-CD40 Monoclonal Antibody CHIR-12.12" @default.
- NCIT_C48405 hasExactSynonym "CHIR-12.12" @default.
- NCIT_C48405 hasExactSynonym "HCD-122" @default.
- NCIT_C48405 hasExactSynonym "LUCATUMUMAB" @default.
- NCIT_C48405 hasExactSynonym "Lucatumumab" @default.
- NCIT_C48405 hasExactSynonym "Monoclonal Antibody CHIR-12.12" @default.
- NCIT_C48405 inSubset NCIT_C116977 @default.
- NCIT_C48405 inSubset NCIT_C116978 @default.
- NCIT_C48405 inSubset NCIT_C128784 @default.
- NCIT_C48405 inSubset NCIT_C157711 @default.
- NCIT_C48405 inSubset NCIT_C157712 @default.
- NCIT_C48405 inSubset NCIT_C176424 @default.
- NCIT_C48405 inSubset NCIT_C177537 @default.
- NCIT_C48405 inSubset NCIT_C63923 @default.
- NCIT_C48405 type Class @default.
- NCIT_C48405 isDefinedBy ncit.owl @default.
- NCIT_C48405 label "Lucatumumab" @default.
- NCIT_C48405 subClassOf NCIT_C129820 @default.
- NCIT_C48405 subClassOf NCIT_C133877 @default.
- NCIT_C48405 subClassOf NCIT_C1908 @default.
- NCIT_C48405 subClassOf NCIT_C1909 @default.
- NCIT_C48405 subClassOf NCIT_C191767 @default.
- NCIT_C48405 subClassOf NCIT_C20401 @default.
- NCIT_C48405 subClassOf NCIT_C274 @default.
- NCIT_C48405 subClassOf NCIT_C307 @default.
- NCIT_C48405 subClassOf NCIT_C308 @default.
- NCIT_C48405 subClassOf NCIT_C48405 @default.