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- NCIT_C48421 IAO_0000115 "A vaccine adjuvant containing CpG 7909, monophosphoryl lipid, and QS-21 with potential antineoplastic and immunostimulatory activities. CpG 7909 is a synthetic 24-mer oligonucleotide containing 3 CpG motifs that selectively targets Toll-like receptor 9 (TLR9), thereby activating dendritic and B cells and stimulating cytotoxic T cell and antibody responses against tumor cells bearing tumor antigens. Monophosphoryl lipid is a detoxified derivative of lipid A, a component of Salmonella minnesota lipopolysaccharide (LPS); this agent may enhance humoral and cellular responses to various antigens. QS-21 is a purified, naturally occurring saponin derived from the South American tree Quillaja saponaria Molina and exhibits various immunostimulatory activities. Combinations of monophosphoryl lipid and QS-21 may be synergistic in inducing humoral and cellular immune responses. (NCI05)" @default.
- NCIT_C48421 NCIT_A7 NCIT_C96048 @default.
- NCIT_C48421 NCIT_NHC0 "C48421" @default.
- NCIT_C48421 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C48421 NCIT_P107 "SB-AS15 Adjuvant" @default.
- NCIT_C48421 NCIT_P108 "SB-AS15 Adjuvant" @default.
- NCIT_C48421 NCIT_P207 "C1541296" @default.
- NCIT_C48421 NCIT_P322 "CTRP" @default.
- NCIT_C48421 NCIT_P329 "373865" @default.
- NCIT_C48421 NCIT_P330 "373865" @default.
- NCIT_C48421 NCIT_P366 "SB-AS15_Adjuvant" @default.
- NCIT_C48421 NCIT_P399 "373865" @default.
- NCIT_C48421 NCIT_R124 NCIT_C17828 @default.
- NCIT_C48421 NCIT_R124 NCIT_C17937 @default.
- NCIT_C48421 NCIT_R124 NCIT_C18095 @default.
- NCIT_C48421 NCIT_R124 NCIT_C18839 @default.
- NCIT_C48421 NCIT_R124 NCIT_C21124 @default.
- NCIT_C48421 NCIT_R124 NCIT_C40912 @default.
- NCIT_C48421 normalizedInformationContent "100" @default.
- NCIT_C48421 referenceCount "1" @default.
- NCIT_C48421 hasExactSynonym "SB AS15" @default.
- NCIT_C48421 hasExactSynonym "SB-AS15 Adjuvant" @default.
- NCIT_C48421 inSubset NCIT_C116977 @default.
- NCIT_C48421 inSubset NCIT_C116978 @default.
- NCIT_C48421 inSubset NCIT_C128784 @default.
- NCIT_C48421 inSubset NCIT_C176424 @default.
- NCIT_C48421 type Class @default.
- NCIT_C48421 isDefinedBy ncit.owl @default.
- NCIT_C48421 label "SB-AS15 Adjuvant" @default.
- NCIT_C48421 subClassOf B3145f41537f01bd30a461afc27ca0ee9 @default.
- NCIT_C48421 subClassOf B8ce38fade84e8a6b5f2c35f938dc88c2 @default.
- NCIT_C48421 subClassOf NCIT_C1908 @default.
- NCIT_C48421 subClassOf NCIT_C1909 @default.
- NCIT_C48421 subClassOf NCIT_C210 @default.
- NCIT_C48421 subClassOf NCIT_C2140 @default.
- NCIT_C48421 subClassOf NCIT_C2554 @default.
- NCIT_C48421 subClassOf NCIT_C308 @default.
- NCIT_C48421 subClassOf NCIT_C48421 @default.