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- NCIT_C488 IAO_0000115 "The trihydrate form of a phosphorylated aminosulfhydryl compound. After dephosphorylation of amifostine by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite, the thiol metabolite binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues." @default.
- NCIT_C488 NCIT_A32 NCIT_C1909 @default.
- NCIT_C488 NCIT_A33 NCIT_C274 @default.
- NCIT_C488 NCIT_NHC0 "C488" @default.
- NCIT_C488 NCIT_P106 "Organic Chemical" @default.
- NCIT_C488 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C488 NCIT_P107 "Amifostine" @default.
- NCIT_C488 NCIT_P108 "Amifostine" @default.
- NCIT_C488 NCIT_P175 "296961" @default.
- NCIT_C488 NCIT_P207 "C0015020" @default.
- NCIT_C488 NCIT_P210 "112901-68-5" @default.
- NCIT_C488 NCIT_P302 "Cisplatin-induced nephrotoxicity; Radiation-induced mucositis and xerostomia" @default.
- NCIT_C488 NCIT_P319 "M487QF2F4V" @default.
- NCIT_C488 NCIT_P322 "CTRP" @default.
- NCIT_C488 NCIT_P322 "FDA" @default.
- NCIT_C488 NCIT_P322 "GDC" @default.
- NCIT_C488 NCIT_P322 "PCDC" @default.
- NCIT_C488 NCIT_P329 "39741" @default.
- NCIT_C488 NCIT_P330 "39741" @default.
- NCIT_C488 NCIT_P350 "C5H15N2O3PS.3H2O" @default.
- NCIT_C488 NCIT_P366 "Amifostine" @default.
- NCIT_C488 NCIT_P375 "Amifostine" @default.
- NCIT_C488 NCIT_P399 "39741" @default.
- NCIT_C488 normalizedInformationContent "75.111529024455209" @default.
- NCIT_C488 referenceCount "43" @default.
- NCIT_C488 hasExactSynonym "2-[(3-Aminopropyl)amino]ethanethiol Dihydrogen Phosphate Ester Trihydrate" @default.
- NCIT_C488 hasExactSynonym "AMIFOSTINE" @default.
- NCIT_C488 hasExactSynonym "APAETP" @default.
- NCIT_C488 hasExactSynonym "Amifostine Trihydrate" @default.
- NCIT_C488 hasExactSynonym "Amifostine" @default.
- NCIT_C488 hasExactSynonym "Aminopropylaminoethylthiophosphoric Acid Trihydrate" @default.
- NCIT_C488 hasExactSynonym "Cytofos" @default.
- NCIT_C488 hasExactSynonym "Ethiofos" @default.
- NCIT_C488 hasExactSynonym "Ethyol" @default.
- NCIT_C488 hasExactSynonym "Gammaphos" @default.
- NCIT_C488 hasExactSynonym "S-(N-(3-Aminopropyl)-2-aminoethyl)thiophosphoric Acid Trihydrate" @default.
- NCIT_C488 hasExactSynonym "S-2-(3-Aminopropylamino)ethylphosphorothioic Acid Trihydrate" @default.
- NCIT_C488 hasExactSynonym "WR 2721" @default.
- NCIT_C488 hasExactSynonym "WR-2721" @default.
- NCIT_C488 hasExactSynonym "WR2721" @default.
- NCIT_C488 hasExactSynonym "YM-08310" @default.
- NCIT_C488 inSubset NCIT_C116977 @default.
- NCIT_C488 inSubset NCIT_C116978 @default.
- NCIT_C488 inSubset NCIT_C128784 @default.
- NCIT_C488 inSubset NCIT_C157711 @default.
- NCIT_C488 inSubset NCIT_C157712 @default.
- NCIT_C488 inSubset NCIT_C176424 @default.
- NCIT_C488 inSubset NCIT_C177383 @default.
- NCIT_C488 inSubset NCIT_C177406 @default.
- NCIT_C488 inSubset NCIT_C177537 @default.
- NCIT_C488 inSubset NCIT_C63923 @default.
- NCIT_C488 type Class @default.
- NCIT_C488 isDefinedBy ncit.owl @default.
- NCIT_C488 label "Amifostine" @default.
- NCIT_C488 subClassOf NCIT_C1908 @default.
- NCIT_C488 subClassOf NCIT_C1909 @default.
- NCIT_C488 subClassOf NCIT_C2080 @default.
- NCIT_C488 subClassOf NCIT_C2459 @default.
- NCIT_C488 subClassOf NCIT_C26170 @default.
- NCIT_C488 subClassOf NCIT_C488 @default.