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- NCIT_C49082 IAO_0000115 "A replication-incompetent, pathotropic, tumor matrix (collagen)-targeted, retroviral vector encoding an N-terminal deletion mutant form of the cyclin G1 gene with potential antineoplastic activity. Under the control of a hybrid long-terminal repeat/cytomegalovirus (CMV) promoter, retrovector encoding mutant anti-cyclin G expresses the mutant cyclin G1 construct, resulting in disruption of tumor cell cyclin G1 activity and decreased cellular proliferation and angiogenesis. This agent preferentially targets collagen of the tumor matrix because of the incorporation of the collagen-binding domain of von Willebrand factor (vWF) on the retrovector surface. Exploiting the collagen-targeting mechanism of vWF permits delivery of the retrovector to tumor sites where angiogenesis and collagen matrix exposure occur." @default.
- NCIT_C49082 NCIT_A32 NCIT_C1909 @default.
- NCIT_C49082 NCIT_NHC0 "C49082" @default.
- NCIT_C49082 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C49082 NCIT_P107 "Retrovector Encoding Mutant Anti-Cyclin G1" @default.
- NCIT_C49082 NCIT_P108 "Retrovector Encoding Mutant Anti-Cyclin G1" @default.
- NCIT_C49082 NCIT_P207 "C1709935" @default.
- NCIT_C49082 NCIT_P322 "CTRP" @default.
- NCIT_C49082 NCIT_P322 "GDC" @default.
- NCIT_C49082 NCIT_P329 "446577" @default.
- NCIT_C49082 NCIT_P330 "446577" @default.
- NCIT_C49082 NCIT_P366 "Retrovector_Encoding_Anti-Cyclin_G" @default.
- NCIT_C49082 NCIT_P375 "Retrovector Encoding Mutant Anti-Cyclin G1" @default.
- NCIT_C49082 NCIT_P399 "446577" @default.
- NCIT_C49082 normalizedInformationContent "100" @default.
- NCIT_C49082 referenceCount "1" @default.
- NCIT_C49082 hasExactSynonym "DeltaRex-G" @default.
- NCIT_C49082 hasExactSynonym "Mx-dnG1" @default.
- NCIT_C49082 hasExactSynonym "REXIN-G" @default.
- NCIT_C49082 hasExactSynonym "Retrovector Encoding Mutant Anti-Cyclin G1" @default.
- NCIT_C49082 inSubset NCIT_C116977 @default.
- NCIT_C49082 inSubset NCIT_C116978 @default.
- NCIT_C49082 inSubset NCIT_C128784 @default.
- NCIT_C49082 inSubset NCIT_C157711 @default.
- NCIT_C49082 inSubset NCIT_C157712 @default.
- NCIT_C49082 inSubset NCIT_C173381 @default.
- NCIT_C49082 inSubset NCIT_C173383 @default.
- NCIT_C49082 inSubset NCIT_C176424 @default.
- NCIT_C49082 inSubset NCIT_C177537 @default.
- NCIT_C49082 type Class @default.
- NCIT_C49082 isDefinedBy ncit.owl @default.
- NCIT_C49082 label "Retrovector Encoding Mutant Anti-Cyclin G1" @default.
- NCIT_C49082 subClassOf NCIT_C1908 @default.
- NCIT_C49082 subClassOf NCIT_C1909 @default.
- NCIT_C49082 subClassOf NCIT_C307 @default.
- NCIT_C49082 subClassOf NCIT_C308 @default.
- NCIT_C49082 subClassOf NCIT_C39619 @default.
- NCIT_C49082 subClassOf NCIT_C49082 @default.
- NCIT_C49082 subClassOf NCIT_C923 @default.