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- NCIT_C49084 IAO_0000115 "A synthetic lipid-conjugated, 13-mer oligonucleotide N3'-P5'-thio-phosphoramidate with potential antineoplastic activity. Complementary to the template region of telomerase (hTR) RNA, imetelstat acts as a competitive enzyme inhibitor that binds and blocks the active site of the enzyme (a telomerase template antagonist), a mechanism of action which differs from that for the antisense oligonucleotide-mediated inhibition of telomerase activity through telomerase mRNA binding. Inhibition of telomerase activity in tumor cells by imetelstat results in telomere shortening, which leads to cell cycle arrest or apoptosis." @default.
- NCIT_C49084 NCIT_A32 NCIT_C1909 @default.
- NCIT_C49084 NCIT_A5 NCIT_C84511 @default.
- NCIT_C49084 NCIT_NHC0 "C49084" @default.
- NCIT_C49084 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C49084 NCIT_P107 "Imetelstat" @default.
- NCIT_C49084 NCIT_P108 "Imetelstat" @default.
- NCIT_C49084 NCIT_P207 "C2746063" @default.
- NCIT_C49084 NCIT_P210 "868169-64-6" @default.
- NCIT_C49084 NCIT_P319 "F60NE4XB53" @default.
- NCIT_C49084 NCIT_P322 "CTRP" @default.
- NCIT_C49084 NCIT_P322 "FDA" @default.
- NCIT_C49084 NCIT_P322 "GDC" @default.
- NCIT_C49084 NCIT_P350 "C148H211N68O53P13S13" @default.
- NCIT_C49084 NCIT_P366 "GRN163L" @default.
- NCIT_C49084 NCIT_P375 "Imetelstat" @default.
- NCIT_C49084 normalizedInformationContent "100" @default.
- NCIT_C49084 referenceCount "1" @default.
- NCIT_C49084 hasExactSynonym "DNA, d(3'-amino-3'-deoxy-P-thio)(T-A-G-G-G-T-T-A-G-A-C-A-A), 5'-[O-[2-hydroxy-3- [(1-oxohexadecyl)amino]propyl] hydrogen phosphorothioate]" @default.
- NCIT_C49084 hasExactSynonym "GRN 163L" @default.
- NCIT_C49084 hasExactSynonym "IMETELSTAT" @default.
- NCIT_C49084 hasExactSynonym "Imetelstat" @default.
- NCIT_C49084 inSubset NCIT_C116977 @default.
- NCIT_C49084 inSubset NCIT_C116978 @default.
- NCIT_C49084 inSubset NCIT_C128784 @default.
- NCIT_C49084 inSubset NCIT_C157711 @default.
- NCIT_C49084 inSubset NCIT_C157712 @default.
- NCIT_C49084 inSubset NCIT_C177537 @default.
- NCIT_C49084 inSubset NCIT_C63923 @default.
- NCIT_C49084 type Class @default.
- NCIT_C49084 isDefinedBy ncit.owl @default.
- NCIT_C49084 label "Imetelstat" @default.
- NCIT_C49084 subClassOf NCIT_C1291 @default.
- NCIT_C49084 subClassOf NCIT_C1908 @default.
- NCIT_C49084 subClassOf NCIT_C1909 @default.
- NCIT_C49084 subClassOf NCIT_C1962 @default.
- NCIT_C49084 subClassOf NCIT_C2826 @default.
- NCIT_C49084 subClassOf NCIT_C307 @default.
- NCIT_C49084 subClassOf NCIT_C471 @default.
- NCIT_C49084 subClassOf NCIT_C49084 @default.