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- NCIT_C49085 IAO_0000115 "A human IgG2 monoclonal antibody directed against the T-cell receptor protein cytotoxic T-lymphocyte-associated protein 4 (CTLA4). Tremelimumab binds to CTLA4 and blocks the binding of the antigen-presenting cell ligands B7-1 and B7-2 to CTLA4, resulting in inhibition of B7-CTLA4-mediated downregulation of T-cell activation; subsequently, B7-1 or B7-2 may interact with another T-cell surface receptor protein, CD28, resulting in a B7-CD28-mediated T-cell activation unopposed by B7-CTLA4-mediated inhibition." @default.
- NCIT_C49085 NCIT_A32 NCIT_C1909 @default.
- NCIT_C49085 NCIT_A7 NCIT_C17489 @default.
- NCIT_C49085 NCIT_NHC0 "C49085" @default.
- NCIT_C49085 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C49085 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C49085 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C49085 NCIT_P107 "Tremelimumab" @default.
- NCIT_C49085 NCIT_P108 "Tremelimumab" @default.
- NCIT_C49085 NCIT_P207 "C2351038" @default.
- NCIT_C49085 NCIT_P210 "745013-59-6" @default.
- NCIT_C49085 NCIT_P302 "for adult patients with unresectable hepatocellular carcinoma (uHCC) in combination with durvalumab." @default.
- NCIT_C49085 NCIT_P319 "QEN1X95CIX" @default.
- NCIT_C49085 NCIT_P322 "CTRP" @default.
- NCIT_C49085 NCIT_P322 "FDA" @default.
- NCIT_C49085 NCIT_P322 "GDC" @default.
- NCIT_C49085 NCIT_P325 "A monoclonal antibody being studied in the treatment of melanoma and some other types of cancer. Ticilimumab is made in the laboratory and binds to a protein called CTLA-4 on T cells (a type of white blood cell). CTLA-4 is involved in preventing the activation of T-cells. Ticilimumab may block CTLA-4 and help the immune system kill cancer cells. It is a type of immunomodulatory agent." @default.
- NCIT_C49085 NCIT_P329 "448620" @default.
- NCIT_C49085 NCIT_P330 "448620" @default.
- NCIT_C49085 NCIT_P366 "Anti-CTLA4_Human_Monoclonal_Antibody_CP-675_206" @default.
- NCIT_C49085 NCIT_P375 "Tremelimumab" @default.
- NCIT_C49085 NCIT_P399 "448620" @default.
- NCIT_C49085 NCIT_R124 NCIT_C17710 @default.
- NCIT_C49085 NCIT_R124 NCIT_C17828 @default.
- NCIT_C49085 NCIT_R124 NCIT_C18219 @default.
- NCIT_C49085 NCIT_R124 NCIT_C19986 @default.
- NCIT_C49085 NCIT_R124 NCIT_C40474 @default.
- NCIT_C49085 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C49085 referenceCount "2" @default.
- NCIT_C49085 hasExactSynonym "Anti-CTLA4 Human Monoclonal Antibody CP-675,206" @default.
- NCIT_C49085 hasExactSynonym "CP-675" @default.
- NCIT_C49085 hasExactSynonym "CP-675,206" @default.
- NCIT_C49085 hasExactSynonym "CP-675206" @default.
- NCIT_C49085 hasExactSynonym "Imjudo" @default.
- NCIT_C49085 hasExactSynonym "Immunoglobulin G2, Anti-(Human CTLA-4 (Antigen)) (Human Monoclonal CP-675206 Clone 11.2.1 Heavy Chain) Disulfide with Human Monoclonal CP-675206 Clone 11.2.1 Light Chain, Dimer" @default.
- NCIT_C49085 hasExactSynonym "TREMELIMUMAB" @default.
- NCIT_C49085 hasExactSynonym "Ticilimumab" @default.
- NCIT_C49085 hasExactSynonym "Tremelimumab" @default.
- NCIT_C49085 hasExactSynonym "Tremelimumab-actl" @default.
- NCIT_C49085 hasExactSynonym "ticilimumab" @default.
- NCIT_C49085 inSubset NCIT_C116977 @default.
- NCIT_C49085 inSubset NCIT_C116978 @default.
- NCIT_C49085 inSubset NCIT_C128784 @default.
- NCIT_C49085 inSubset NCIT_C157711 @default.
- NCIT_C49085 inSubset NCIT_C157712 @default.
- NCIT_C49085 inSubset NCIT_C176424 @default.
- NCIT_C49085 inSubset NCIT_C177537 @default.
- NCIT_C49085 inSubset NCIT_C63923 @default.
- NCIT_C49085 type Class @default.
- NCIT_C49085 isDefinedBy ncit.owl @default.
- NCIT_C49085 label "Tremelimumab" @default.
- NCIT_C49085 subClassOf NCIT_C128036 @default.
- NCIT_C49085 subClassOf NCIT_C141144 @default.
- NCIT_C49085 subClassOf NCIT_C143250 @default.
- NCIT_C49085 subClassOf NCIT_C163758 @default.
- NCIT_C49085 subClassOf NCIT_C1908 @default.
- NCIT_C49085 subClassOf NCIT_C1909 @default.
- NCIT_C49085 subClassOf NCIT_C191738 @default.
- NCIT_C49085 subClassOf NCIT_C20401 @default.
- NCIT_C49085 subClassOf NCIT_C274 @default.
- NCIT_C49085 subClassOf NCIT_C307 @default.
- NCIT_C49085 subClassOf NCIT_C308 @default.
- NCIT_C49085 subClassOf NCIT_C49085 @default.