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- NCIT_C49094 IAO_0000115 "An orally available, 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Treatment of cells with this agent results in inhibition of downstream signal transduction events and cell cycle regulatory pathways; arrest at the G1-S (Gap 1/DNA synthesis)-phase transition of the cell division cycle; and ultimately decreased cellular proliferation. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells." @default.
- NCIT_C49094 NCIT_A32 NCIT_C1909 @default.
- NCIT_C49094 NCIT_NHC0 "C49094" @default.
- NCIT_C49094 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C49094 NCIT_P107 "Neratinib" @default.
- NCIT_C49094 NCIT_P108 "Neratinib" @default.
- NCIT_C49094 NCIT_P207 "C1704439" @default.
- NCIT_C49094 NCIT_P210 "698387-09-6" @default.
- NCIT_C49094 NCIT_P302 "early stage HER2-overexpressed/amplified breast cancer" @default.
- NCIT_C49094 NCIT_P319 "JJH94R3PWB" @default.
- NCIT_C49094 NCIT_P322 "CTRP" @default.
- NCIT_C49094 NCIT_P322 "FDA" @default.
- NCIT_C49094 NCIT_P322 "GDC" @default.
- NCIT_C49094 NCIT_P329 "453548" @default.
- NCIT_C49094 NCIT_P330 "453548" @default.
- NCIT_C49094 NCIT_P350 "C30H29ClN6O3" @default.
- NCIT_C49094 NCIT_P366 "KI-272" @default.
- NCIT_C49094 NCIT_P368 "CHEBI:61397" @default.
- NCIT_C49094 NCIT_P375 "Neratinib" @default.
- NCIT_C49094 NCIT_P399 "453548" @default.
- NCIT_C49094 normalizedInformationContent "100" @default.
- NCIT_C49094 referenceCount "1" @default.
- NCIT_C49094 hasExactSynonym "(2E)-N-(4-((3-chloro-4-((pyridin-2-yl)methoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide" @default.
- NCIT_C49094 hasExactSynonym "2-Butenamide, N-(4-((3-chloro-4-(2-pyridinylmethoxy)phenyl)amino)-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-, (2E)-" @default.
- NCIT_C49094 hasExactSynonym "HKI 272" @default.
- NCIT_C49094 hasExactSynonym "HKI-272" @default.
- NCIT_C49094 hasExactSynonym "NERATINIB" @default.
- NCIT_C49094 hasExactSynonym "Neratinib" @default.
- NCIT_C49094 hasExactSynonym "PB 272" @default.
- NCIT_C49094 hasExactSynonym "PB-272" @default.
- NCIT_C49094 inSubset NCIT_C116977 @default.
- NCIT_C49094 inSubset NCIT_C116978 @default.
- NCIT_C49094 inSubset NCIT_C128784 @default.
- NCIT_C49094 inSubset NCIT_C157711 @default.
- NCIT_C49094 inSubset NCIT_C157712 @default.
- NCIT_C49094 inSubset NCIT_C176424 @default.
- NCIT_C49094 inSubset NCIT_C177537 @default.
- NCIT_C49094 inSubset NCIT_C63923 @default.
- NCIT_C49094 type Class @default.
- NCIT_C49094 isDefinedBy ncit.owl @default.
- NCIT_C49094 label "Neratinib" @default.
- NCIT_C49094 subClassOf NCIT_C129824 @default.
- NCIT_C49094 subClassOf NCIT_C129825 @default.
- NCIT_C49094 subClassOf NCIT_C1404 @default.
- NCIT_C49094 subClassOf NCIT_C159156 @default.
- NCIT_C49094 subClassOf NCIT_C163758 @default.
- NCIT_C49094 subClassOf NCIT_C163760 @default.
- NCIT_C49094 subClassOf NCIT_C1908 @default.
- NCIT_C49094 subClassOf NCIT_C1909 @default.
- NCIT_C49094 subClassOf NCIT_C1967 @default.
- NCIT_C49094 subClassOf NCIT_C2189 @default.
- NCIT_C49094 subClassOf NCIT_C274 @default.
- NCIT_C49094 subClassOf NCIT_C471 @default.
- NCIT_C49094 subClassOf NCIT_C49094 @default.