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- NCIT_C49095 IAO_0000115 "A second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. Based on the chemistry of SP600125, another anthrapyrazolone inhibitor of JNK, CC-401 competitively binds the ATP binding site of JNK, resulting in inhibition of the phosphorylation of the N-terminal activation domain of transcription factor c-Jun; decreased transcription activity of c-Jun; and a variety of cellular effects including decreased cellular proliferation." @default.
- NCIT_C49095 NCIT_A32 NCIT_C1909 @default.
- NCIT_C49095 NCIT_NHC0 "C49095" @default.
- NCIT_C49095 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C49095 NCIT_P108 "JNK Inhibitor CC-401" @default.
- NCIT_C49095 NCIT_P208 "CL937289" @default.
- NCIT_C49095 NCIT_P210 "395104-30-0" @default.
- NCIT_C49095 NCIT_P319 "NOE38VQA1W" @default.
- NCIT_C49095 NCIT_P322 "FDA" @default.
- NCIT_C49095 NCIT_P322 "GDC" @default.
- NCIT_C49095 NCIT_P329 "453550" @default.
- NCIT_C49095 NCIT_P330 "453550" @default.
- NCIT_C49095 NCIT_P366 "CC-401" @default.
- NCIT_C49095 NCIT_P375 "JNK Inhibitor CC-401" @default.
- NCIT_C49095 NCIT_P399 "453550" @default.
- NCIT_C49095 normalizedInformationContent "100" @default.
- NCIT_C49095 referenceCount "1" @default.
- NCIT_C49095 hasExactSynonym "CC-401" @default.
- NCIT_C49095 hasExactSynonym "JNK Inhibitor CC-401" @default.
- NCIT_C49095 inSubset NCIT_C128784 @default.
- NCIT_C49095 inSubset NCIT_C157711 @default.
- NCIT_C49095 inSubset NCIT_C157712 @default.
- NCIT_C49095 inSubset NCIT_C176424 @default.
- NCIT_C49095 inSubset NCIT_C177537 @default.
- NCIT_C49095 inSubset NCIT_C63923 @default.
- NCIT_C49095 type Class @default.
- NCIT_C49095 isDefinedBy ncit.owl @default.
- NCIT_C49095 label "JNK Inhibitor CC-401" @default.
- NCIT_C49095 subClassOf NCIT_C1404 @default.
- NCIT_C49095 subClassOf NCIT_C163758 @default.
- NCIT_C49095 subClassOf NCIT_C1908 @default.
- NCIT_C49095 subClassOf NCIT_C1909 @default.
- NCIT_C49095 subClassOf NCIT_C2149 @default.
- NCIT_C49095 subClassOf NCIT_C274 @default.
- NCIT_C49095 subClassOf NCIT_C471 @default.
- NCIT_C49095 subClassOf NCIT_C49095 @default.
- NCIT_C49095 subClassOf NCIT_C61074 @default.