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- NCIT_C49096 IAO_0000115 "A synthetic trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity. Alvimopan is a selective and competitive antagonist at mu-opioid receptors, found in myenteric and submucosal neurons and the immune cells of the lamina propria in the human gut. Upon administration, this agent binds to mu-opioid receptors in the gut, thereby reversing opioid-related disturbances in gut motility. Alvimopan is approximately three to nine times more potent than naloxone." @default.
- NCIT_C49096 NCIT_NHC0 "C49096" @default.
- NCIT_C49096 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C49096 NCIT_P107 "Alvimopan" @default.
- NCIT_C49096 NCIT_P108 "Alvimopan" @default.
- NCIT_C49096 NCIT_P207 "C1508750" @default.
- NCIT_C49096 NCIT_P210 "170098-38-1" @default.
- NCIT_C49096 NCIT_P319 "677C126AET" @default.
- NCIT_C49096 NCIT_P322 "CTRP" @default.
- NCIT_C49096 NCIT_P322 "FDA" @default.
- NCIT_C49096 NCIT_P329 "453551" @default.
- NCIT_C49096 NCIT_P330 "453551" @default.
- NCIT_C49096 NCIT_P350 "C25H32N2O4.2H2O" @default.
- NCIT_C49096 NCIT_P366 "Alvimopan" @default.
- NCIT_C49096 NCIT_P399 "453551" @default.
- NCIT_C49096 normalizedInformationContent "100" @default.
- NCIT_C49096 referenceCount "1" @default.
- NCIT_C49096 hasExactSynonym "ADL8-2698" @default.
- NCIT_C49096 hasExactSynonym "ALVIMOPAN" @default.
- NCIT_C49096 hasExactSynonym "Alvimopan" @default.
- NCIT_C49096 hasExactSynonym "Entereg" @default.
- NCIT_C49096 hasExactSynonym "LY-246376" @default.
- NCIT_C49096 inSubset NCIT_C116977 @default.
- NCIT_C49096 inSubset NCIT_C116978 @default.
- NCIT_C49096 inSubset NCIT_C176424 @default.
- NCIT_C49096 inSubset NCIT_C63923 @default.
- NCIT_C49096 type Class @default.
- NCIT_C49096 isDefinedBy ncit.owl @default.
- NCIT_C49096 label "Alvimopan" @default.
- NCIT_C49096 subClassOf NCIT_C1908 @default.
- NCIT_C49096 subClassOf NCIT_C1909 @default.
- NCIT_C49096 subClassOf NCIT_C49096 @default.
- NCIT_C49096 subClassOf NCIT_C681 @default.
- NCIT_C49096 subClassOf NCIT_C78272 @default.