Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C49178> ?p ?o ?g. }
Showing items 1 to 45 of
45
with 100 items per page.
- NCIT_C49178 IAO_0000115 "A nanoparticle-based formulation composed of a non-viral plasmid DNA vector encoding the human pro-inflammatory cytokine interleukin-12 (IL-12) encapsulated in a biodegradable, biocompatible lipoplex composed of polyethylene glycol (PEG), polyethylenimine (PEI), and cholesterol, with potential immunoactivating and antineoplastic activities. Upon intraperitoneal (IP) delivery of the PEG-PEI-cholesterol lipopolymer-encased IL-12 DNA plasmid vector IMNN-001, the lipoplex is endocytosed by nearby cells, and the plasmid DNA is transported into the nucleus, which leads to local expresssion of IL-12. In turn, the increased IL-12 production at the tumor site activates the immune system by promoting the activation of natural killer cells (NKs), inducing secretion of interferon-gamma (IFN-g) and promoting cytotoxic T-cell responses against tumor cells." @default.
- NCIT_C49178 NCIT_A32 NCIT_C1909 @default.
- NCIT_C49178 NCIT_NHC0 "C49178" @default.
- NCIT_C49178 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C49178 NCIT_P107 "PEG-PEI-cholesterol Lipopolymer-encased IL-12 DNA Plasmid Vector IMNN-001" @default.
- NCIT_C49178 NCIT_P108 "PEG-PEI-cholesterol Lipopolymer-encased IL-12 DNA Plasmid Vector IMNN-001" @default.
- NCIT_C49178 NCIT_P207 "C1707844" @default.
- NCIT_C49178 NCIT_P322 "CTRP" @default.
- NCIT_C49178 NCIT_P322 "GDC" @default.
- NCIT_C49178 NCIT_P329 "454593" @default.
- NCIT_C49178 NCIT_P330 "454593" @default.
- NCIT_C49178 NCIT_P366 "EGEN-001" @default.
- NCIT_C49178 NCIT_P375 "PEG-PEI-cholesterol Lipopolymer-encased IL-12 DNA Plasmid Vector GEN-1" @default.
- NCIT_C49178 NCIT_P399 "454593" @default.
- NCIT_C49178 normalizedInformationContent "100" @default.
- NCIT_C49178 referenceCount "1" @default.
- NCIT_C49178 hasExactSynonym "GEN 1" @default.
- NCIT_C49178 hasExactSynonym "GEN-1" @default.
- NCIT_C49178 hasExactSynonym "GEN1" @default.
- NCIT_C49178 hasExactSynonym "IL-12 Plasmid Formulated With PEG-PEI-Cholesterol Lipopolymer" @default.
- NCIT_C49178 hasExactSynonym "IMNN 001" @default.
- NCIT_C49178 hasExactSynonym "IMNN-001" @default.
- NCIT_C49178 hasExactSynonym "IMNN001" @default.
- NCIT_C49178 hasExactSynonym "Nanoparticle-encased IL-12 DNA Plasmid Vector" @default.
- NCIT_C49178 hasExactSynonym "PEG-PEI-cholesterol Lipopolymer-encased IL-12 DNA Plasmid Vector IMNN-001" @default.
- NCIT_C49178 hasExactSynonym "phIL-12-005" @default.
- NCIT_C49178 inSubset NCIT_C116977 @default.
- NCIT_C49178 inSubset NCIT_C116978 @default.
- NCIT_C49178 inSubset NCIT_C128784 @default.
- NCIT_C49178 inSubset NCIT_C157711 @default.
- NCIT_C49178 inSubset NCIT_C157712 @default.
- NCIT_C49178 inSubset NCIT_C176424 @default.
- NCIT_C49178 inSubset NCIT_C177537 @default.
- NCIT_C49178 type Class @default.
- NCIT_C49178 isDefinedBy ncit.owl @default.
- NCIT_C49178 label "PEG-PEI-cholesterol Lipopolymer-encased IL-12 DNA Plasmid Vector IMNN-001" @default.
- NCIT_C49178 subClassOf NCIT_C129820 @default.
- NCIT_C49178 subClassOf NCIT_C1908 @default.
- NCIT_C49178 subClassOf NCIT_C1909 @default.
- NCIT_C49178 subClassOf NCIT_C1962 @default.
- NCIT_C49178 subClassOf NCIT_C274 @default.
- NCIT_C49178 subClassOf NCIT_C307 @default.
- NCIT_C49178 subClassOf NCIT_C308 @default.
- NCIT_C49178 subClassOf NCIT_C49178 @default.
- NCIT_C49178 subClassOf NCIT_C61199 @default.