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- NCIT_C49180 IAO_0000115 "A second-generation synthetic antisense oligonucleotide with potential antineoplastic activity. AEG35156 selectively blocks the cellular expression of X-linked inhibitor of apoptosis protein (XIAP), a pivotal inhibitor of apoptosis that is overexpressed in many tumors. This agent reduces total levels of XIAP in tumor cells, working synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis. XIAP interferes with both the intrinsic and extrinsic program-death signaling pathways, which may render tumor cells resistant to apoptosis." @default.
- NCIT_C49180 NCIT_A32 NCIT_C1909 @default.
- NCIT_C49180 NCIT_A7 NCIT_C20947 @default.
- NCIT_C49180 NCIT_NHC0 "C49180" @default.
- NCIT_C49180 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C49180 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C49180 NCIT_P107 "XIAP Antisense Oligonucleotide AEG35156" @default.
- NCIT_C49180 NCIT_P108 "XIAP Antisense Oligonucleotide AEG35156" @default.
- NCIT_C49180 NCIT_P207 "C1567121" @default.
- NCIT_C49180 NCIT_P322 "CTRP" @default.
- NCIT_C49180 NCIT_P322 "GDC" @default.
- NCIT_C49180 NCIT_P325 "A substance being studied in the treatment of cancer. AEG35156 may kill cancer cells by blocking the production of a protein called XIAP that helps cells live longer. It also makes cancer cells more sensitive to anticancer drugs. It is a type of antisense oligonucleotide, and a type of chemosensitizing agent." @default.
- NCIT_C49180 NCIT_P329 "492218" @default.
- NCIT_C49180 NCIT_P330 "492218" @default.
- NCIT_C49180 NCIT_P366 "AEG35156" @default.
- NCIT_C49180 NCIT_P375 "XIAP Antisense Oligonucleotide AEG35156" @default.
- NCIT_C49180 NCIT_P399 "492218" @default.
- NCIT_C49180 normalizedInformationContent "100" @default.
- NCIT_C49180 referenceCount "1" @default.
- NCIT_C49180 hasExactSynonym "AEG35156" @default.
- NCIT_C49180 hasExactSynonym "GEM640" @default.
- NCIT_C49180 hasExactSynonym "XIAP Antisense Oligonucleotide AEG35156" @default.
- NCIT_C49180 inSubset NCIT_C116977 @default.
- NCIT_C49180 inSubset NCIT_C116978 @default.
- NCIT_C49180 inSubset NCIT_C128784 @default.
- NCIT_C49180 inSubset NCIT_C157711 @default.
- NCIT_C49180 inSubset NCIT_C157712 @default.
- NCIT_C49180 inSubset NCIT_C176424 @default.
- NCIT_C49180 inSubset NCIT_C177537 @default.
- NCIT_C49180 type Class @default.
- NCIT_C49180 isDefinedBy ncit.owl @default.
- NCIT_C49180 label "XIAP Antisense Oligonucleotide AEG35156" @default.
- NCIT_C49180 subClassOf NCIT_C1291 @default.
- NCIT_C49180 subClassOf NCIT_C1908 @default.
- NCIT_C49180 subClassOf NCIT_C1909 @default.
- NCIT_C49180 subClassOf NCIT_C1962 @default.
- NCIT_C49180 subClassOf NCIT_C307 @default.
- NCIT_C49180 subClassOf NCIT_C49180 @default.