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- NCIT_C49181 IAO_0000115 "An orally available, synthetic small molecule with potential antineoplastic activity. AVN944 inhibits inosine monosphosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanosine triphosphate (GTP), a purine molecule required for DNA and RNA synthesis. Inhibition of IMPDH deprives cancer cells of GTP, resulting in disruption of DNA and RNA synthesis, inhibition of cell proliferation, and the induction of apoptosis. AVN944 appears to have a selective effect on cancer cells in that deprivation of GTP in normal cells results in a temporary slowing of cell growth only. IMPDH is overexpressed in some cancer cells, particularly in hematological malignancies." @default.
- NCIT_C49181 NCIT_A32 NCIT_C1909 @default.
- NCIT_C49181 NCIT_NHC0 "C49181" @default.
- NCIT_C49181 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C49181 NCIT_P108 "Inosine Monophosphate Dehydrogenase Inhibitor AVN944" @default.
- NCIT_C49181 NCIT_P207 "C1706677" @default.
- NCIT_C49181 NCIT_P210 "297730-17-7" @default.
- NCIT_C49181 NCIT_P319 "I3NPL1V48Q" @default.
- NCIT_C49181 NCIT_P322 "FDA" @default.
- NCIT_C49181 NCIT_P322 "GDC" @default.
- NCIT_C49181 NCIT_P325 "A substance being studied in the treatment of cancer. It blocks cells from making DNA and RNA and may kill cancer cells. It is a type of inosine monophosphate dehydrogenase (IMPDH) inhibitor." @default.
- NCIT_C49181 NCIT_P329 "486333" @default.
- NCIT_C49181 NCIT_P330 "486333" @default.
- NCIT_C49181 NCIT_P350 "C25H27N5O5" @default.
- NCIT_C49181 NCIT_P366 "AVN944" @default.
- NCIT_C49181 NCIT_P375 "Inosine Monophosphate Dehydrogenase Inhibitor AVN944" @default.
- NCIT_C49181 NCIT_P399 "486333" @default.
- NCIT_C49181 normalizedInformationContent "100" @default.
- NCIT_C49181 referenceCount "1" @default.
- NCIT_C49181 hasExactSynonym "AVN-944" @default.
- NCIT_C49181 hasExactSynonym "AVN944" @default.
- NCIT_C49181 hasExactSynonym "Inosine Monophosphate Dehydrogenase Inhibitor AVN944" @default.
- NCIT_C49181 inSubset NCIT_C128784 @default.
- NCIT_C49181 inSubset NCIT_C157711 @default.
- NCIT_C49181 inSubset NCIT_C157712 @default.
- NCIT_C49181 inSubset NCIT_C176424 @default.
- NCIT_C49181 inSubset NCIT_C177537 @default.
- NCIT_C49181 inSubset NCIT_C63923 @default.
- NCIT_C49181 type Class @default.
- NCIT_C49181 isDefinedBy ncit.owl @default.
- NCIT_C49181 label "Inosine Monophosphate Dehydrogenase Inhibitor AVN944" @default.
- NCIT_C49181 subClassOf NCIT_C1908 @default.
- NCIT_C49181 subClassOf NCIT_C1909 @default.
- NCIT_C49181 subClassOf NCIT_C2087 @default.
- NCIT_C49181 subClassOf NCIT_C471 @default.
- NCIT_C49181 subClassOf NCIT_C49181 @default.