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NCIT_C49350 IAO_0000115 "Human BCL2 wild-type allele is located in the vicinity of 18q21.3 and is approximately195 kb in length. This mitochondrial allele, which encodes apoptosis regulator Bcl-2 protein, is involved in apoptosis and sub-cellular signal transduction." @default.
NCIT_C49350 NCIT_NHC0 "C49350" @default.
NCIT_C49350 NCIT_P100 "151430" @default.
NCIT_C49350 NCIT_P102 "M14745" @default.
NCIT_C49350 NCIT_P102 "NM_000633" @default.
NCIT_C49350 NCIT_P106 "Gene or Genome" @default.
NCIT_C49350 NCIT_P107 "BCL2 wt Allele" @default.
NCIT_C49350 NCIT_P108 "BCL2 wt Allele" @default.
NCIT_C49350 NCIT_P207 "C1704467" @default.
NCIT_C49350 NCIT_P211 "anti-apoptosis" @default.
NCIT_C49350 NCIT_P211 "apoptosis inhibitor activity" @default.
NCIT_C49350 NCIT_P211 "humoral immune response" @default.
NCIT_C49350 NCIT_P211 "mitochondrial inner membrane" @default.
NCIT_C49350 NCIT_P211 "negative regulation of cell proliferation" @default.
NCIT_C49350 NCIT_P211 "regulation of cell cycle" @default.
NCIT_C49350 NCIT_P321 "596" @default.
NCIT_C49350 NCIT_P322 "CTRP" @default.
NCIT_C49350 NCIT_P366 "BCL2_wt_Allele" @default.
NCIT_C49350 NCIT_P96 "B-cell CLL/lymphoma 2" @default.
NCIT_C49350 NCIT_P98 "The BCL-2 gene encodes two isoforms from alternative splicing of the mitochondrial membrane protein BCL-2, which exhibits anti-apoptotic activity promoted by growth factor-stimulated phosphorylation by PKC. Cleavage of BCL-2 by caspases during apoptosis yields a pro-apoptotic product that stimulates further caspase activity, due to release of mitochondrial cytochrome C into the cytosol. Gene transcription is up regulated by IL2. BCL-2 consists of two exons separated by an intron. These mRNAs encode alpha and beta isoforms, identical except for the carboxyl terminus. Overexpression of BCL-2 from a t(14;18) translocation with the Ig gene region promotes B-cell lymphomas, due to interference with apoptosis." @default.
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