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- NCIT_C49362 IAO_0000115 "Human BIRC7 wild-type allele is located in the vicinity of 20q13.3 and is approximately 5 kb in length. This allele, which encodes baculoviral IAP repeat-containing protein 7, plays a role in anti-apoptotic processes." @default.
- NCIT_C49362 NCIT_NHC0 "C49362" @default.
- NCIT_C49362 NCIT_P100 "605737" @default.
- NCIT_C49362 NCIT_P102 "NM_022161" @default.
- NCIT_C49362 NCIT_P106 "Gene or Genome" @default.
- NCIT_C49362 NCIT_P107 "BIRC7 wt Allele" @default.
- NCIT_C49362 NCIT_P108 "BIRC7 wt Allele" @default.
- NCIT_C49362 NCIT_P207 "C1705226" @default.
- NCIT_C49362 NCIT_P211 "DNA fragmentation" @default.
- NCIT_C49362 NCIT_P211 "activation of JUNK" @default.
- NCIT_C49362 NCIT_P211 "apoptosis inhibitor activity" @default.
- NCIT_C49362 NCIT_P211 "enzyme binding" @default.
- NCIT_C49362 NCIT_P211 "inhibition of caspase activation" @default.
- NCIT_C49362 NCIT_P211 "intracellular" @default.
- NCIT_C49362 NCIT_P321 "79444" @default.
- NCIT_C49362 NCIT_P322 "CTRP" @default.
- NCIT_C49362 NCIT_P366 "BIRC7_wt_Allele" @default.
- NCIT_C49362 NCIT_P96 "Livin" @default.
- NCIT_C49362 NCIT_P98 "BIRC7 has pleiotropic effects on apoptosis induced by various stimuli. BIRC7's anti-apoptotic activity is achieved by two separate mechanisms: one requiring TAK1-dependent JNK1 activation and the second involving caspase inhibition. Upon receipt of a death stimulus, SMAC is processed to its active form and interacts with the BIR (baculovirus IAP repeat) domain of BIRC7 to abrogate the ability of BIRC7 to inhibit apoptosis. Two splicing variants, alpha and beta, have different biological properties and tissue distribution pattern though both have a significant antiapoptotic activity. The protein encoded by the BIRC7 gene is a potent anti-cell death protein and caspase inhibitor." @default.
- NCIT_C49362 NCIT_R145 NCIT_C12219 @default.
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- NCIT_C49362 NCIT_R37 NCIT_C51037 @default.
- NCIT_C49362 NCIT_R40 NCIT_C12219 @default.
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- NCIT_C49362 NCIT_R40 NCIT_C14135 @default.
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- NCIT_C49362 NCIT_R40 NCIT_C34070 @default.
- NCIT_C49362 NCIT_R41 NCIT_C14182 @default.
- NCIT_C49362 NCIT_R41 NCIT_C14225 @default.
- NCIT_C49362 NCIT_R41 NCIT_C14234 @default.
- NCIT_C49362 NCIT_R41 NCIT_C14250 @default.
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- NCIT_C49362 NCIT_R41 NCIT_C14282 @default.
- NCIT_C49362 NCIT_R41 NCIT_C25796 @default.
- NCIT_C49362 NCIT_R41 NCIT_C79740 @default.
- NCIT_C49362 normalizedInformationContent "100" @default.
- NCIT_C49362 referenceCount "1" @default.
- NCIT_C49362 hasExactSynonym "BIRC7 wt Allele" @default.
- NCIT_C49362 hasExactSynonym "Baculoviral IAP Repeat-Containing 7 (Livin) wt Allele" @default.
- NCIT_C49362 hasExactSynonym "Baculoviral IAP Repeat-Containing 7 Gene" @default.
- NCIT_C49362 hasExactSynonym "Baculoviral IAP Repeat-Containing Protein 7 Gene" @default.
- NCIT_C49362 hasExactSynonym "KIAP" @default.
- NCIT_C49362 hasExactSynonym "LIVIN" @default.
- NCIT_C49362 hasExactSynonym "ML-IAP" @default.
- NCIT_C49362 hasExactSynonym "MLIAP" @default.
- NCIT_C49362 inSubset NCIT_C116977 @default.
- NCIT_C49362 inSubset NCIT_C142799 @default.
- NCIT_C49362 inSubset NCIT_C142800 @default.
- NCIT_C49362 type Class @default.
- NCIT_C49362 isDefinedBy ncit.owl @default.
- NCIT_C49362 label "BIRC7 wt Allele" @default.
- NCIT_C49362 subClassOf NCIT_C16612 @default.
- NCIT_C49362 subClassOf NCIT_C20347 @default.
- NCIT_C49362 subClassOf NCIT_C20353 @default.
- NCIT_C49362 subClassOf NCIT_C20462 @default.
- NCIT_C49362 subClassOf NCIT_C20938 @default.
- NCIT_C49362 subClassOf NCIT_C49362 @default.
- NCIT_C49362 equivalentClass B3028d703785d689dde9ec45b238f6bed @default.
- NCIT_C49362 equivalentClass B5232713ca97ef6d178db43241c49ac14 @default.