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- NCIT_C49364 IAO_0000115 "Human APAF1 wild-type allele is located in the vicinity of 9q22.32 and is approximately 90 kb in length. This allele, which encodes apoptotic protease-activating factor 1, plays a role in the mediation of caspase cleavage and the propagation of apoptosis. APAF1 allele is inactivated in metastatic melanomas, leading to defects in the execution of apoptotic cell death and chemoresistance." @default.
- NCIT_C49364 NCIT_NHC0 "C49364" @default.
- NCIT_C49364 NCIT_P100 "602233" @default.
- NCIT_C49364 NCIT_P102 "NM_013229" @default.
- NCIT_C49364 NCIT_P106 "Gene or Genome" @default.
- NCIT_C49364 NCIT_P107 "APAF1 wt Allele" @default.
- NCIT_C49364 NCIT_P108 "APAF1 wt Allele" @default.
- NCIT_C49364 NCIT_P207 "C1706666" @default.
- NCIT_C49364 NCIT_P211 "apoptosis regulator activity" @default.
- NCIT_C49364 NCIT_P211 "apoptosis" @default.
- NCIT_C49364 NCIT_P211 "caspase activator activity" @default.
- NCIT_C49364 NCIT_P211 "cellular_component unknown" @default.
- NCIT_C49364 NCIT_P211 "cytosol" @default.
- NCIT_C49364 NCIT_P211 "neurogenesis" @default.
- NCIT_C49364 NCIT_P321 "317" @default.
- NCIT_C49364 NCIT_P322 "CTRP" @default.
- NCIT_C49364 NCIT_P366 "APAF1_wt_Allele" @default.
- NCIT_C49364 NCIT_P96 "Apoptotic Protease Activating Factor 1" @default.
- NCIT_C49364 NCIT_P98 "The protein encoded by the APAF1 gene mediates processing of procaspase-9 by oligomerizing the precursors of procaspase-9 autoactivation and assembling the apoptosome complex. Once activated, caspase-9 initiates a biochemical cascade involving the downstream executioners caspase-3, -6, and -7. In addition, binding of cytochrome c to APAF1 triggers the activation of caspase-3 in the cytochrome c/dATP-dependent apoptotic pathway. APAF1 is inactivated in metastatic melanomas, leading to defects in the execution of apoptotic cell death and chemoresistance." @default.
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- NCIT_C49364 hasExactSynonym "APAF1 wt Allele" @default.
- NCIT_C49364 hasExactSynonym "Apoptotic Protease Activating Factor 1 wt Allele" @default.
- NCIT_C49364 hasExactSynonym "KIAA0413" @default.
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- NCIT_C49364 type Class @default.
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- NCIT_C49364 label "APAF1 wt Allele" @default.
- NCIT_C49364 subClassOf NCIT_C16612 @default.
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