Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C49368> ?p ?o ?g. }
- NCIT_C49368 IAO_0000115 "Human BAX wild-type allele is located within 19q13.33 and is approximately 7 kb in length. This allele, which encodes apoptosis regulator BAX protein, plays a role in the regulation of the apoptotic program by varying the permeability of the mitochondrial membrane." @default.
- NCIT_C49368 NCIT_NHC0 "C49368" @default.
- NCIT_C49368 NCIT_P100 "600040" @default.
- NCIT_C49368 NCIT_P102 "L22474" @default.
- NCIT_C49368 NCIT_P102 "NM_004324" @default.
- NCIT_C49368 NCIT_P106 "Gene or Genome" @default.
- NCIT_C49368 NCIT_P107 "BAX wt Allele" @default.
- NCIT_C49368 NCIT_P108 "BAX wt Allele" @default.
- NCIT_C49368 NCIT_P207 "C1706879" @default.
- NCIT_C49368 NCIT_P211 "apoptotic mitochondrial changes" @default.
- NCIT_C49368 NCIT_P211 "cellular_component unknown" @default.
- NCIT_C49368 NCIT_P211 "germ-cell development" @default.
- NCIT_C49368 NCIT_P211 "induction of apoptosis by extracellular signals" @default.
- NCIT_C49368 NCIT_P211 "induction of apoptosis" @default.
- NCIT_C49368 NCIT_P211 "molecular_function unknown" @default.
- NCIT_C49368 NCIT_P211 "negative regulation of survival gene products" @default.
- NCIT_C49368 NCIT_P321 "581" @default.
- NCIT_C49368 NCIT_P322 "CTRP" @default.
- NCIT_C49368 NCIT_P366 "BAX_wt_Allele" @default.
- NCIT_C49368 NCIT_P96 "BCL2-Associated X Protein" @default.
- NCIT_C49368 NCIT_P98 "BAX shows extensive amino acid homology with BCL2 and forms homo- and heterodimers with BCL2, which controls mitochondrial membrane permeability. The ratio of BAX to BCL2 may determine survival or death following an apoptotic stimulus. BAX binds to PTPC, the mitochondrial porin channel VDAC, involved in regulation of mitochondrial membrane permeability. BAX and mitochondrial protein ANT cooperate within PTPC to increase mitochondrial membrane permeability, which causes release of cytochrome C into the cytoplasm, activating death-driving proteolytic caspases. Its promoter contains consensus p53-binding sites. A primary-response gene for p53, BAX is involved in a p53-regulated pathway for induction of apoptosis." @default.
- NCIT_C49368 NCIT_P98 "The BAX gene is expressed as 4 distinct isoforms (alpha, beta, gamma and delta) generated by alternative splicing. The alpha form is a membrane localized protein and the other 3 are cytoplasmic." @default.
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