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- NCIT_C494 IAO_0000115 "A synthetic, lipophilic phenylpiperidine opioid agonist with analgesic and anesthetic properties. Fentanyl selectively binds to and activates the mu-receptor in the central nervous system (CNS) thereby mimicking the effects of endogenous opiates. Activation of the mu-subtype opioid receptor stimulates the exchange of GTP for GDP on the G-protein complex and subsequently inhibits adenylate cyclase. This causes a decrease in intracellular cAMP which inhibits cAMP-mediated calcium influx into the cell via the calcium channels and thereby results in hyperpolarization and reduced neuronal excitability." @default.
- NCIT_C494 NCIT_A5 NCIT_C47994 @default.
- NCIT_C494 NCIT_A5 NCIT_C61762 @default.
- NCIT_C494 NCIT_NHC0 "C494" @default.
- NCIT_C494 NCIT_P106 "Organic Chemical" @default.
- NCIT_C494 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C494 NCIT_P107 "Fentanyl" @default.
- NCIT_C494 NCIT_P108 "Fentanyl" @default.
- NCIT_C494 NCIT_P207 "C0591423" @default.
- NCIT_C494 NCIT_P210 "437-38-7" @default.
- NCIT_C494 NCIT_P319 "UF599785JZ" @default.
- NCIT_C494 NCIT_P322 "CTRP" @default.
- NCIT_C494 NCIT_P322 "FDA" @default.
- NCIT_C494 NCIT_P350 "C22H28N2O" @default.
- NCIT_C494 NCIT_P366 "Fentanyl" @default.
- NCIT_C494 NCIT_P368 "CHEBI:119915" @default.
- NCIT_C494 NCIT_R122 NCIT_C16484 @default.
- NCIT_C494 NCIT_R122 NCIT_C16486 @default.
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- NCIT_C494 NCIT_R122 NCIT_C16865 @default.
- NCIT_C494 NCIT_R122 NCIT_C16946 @default.
- NCIT_C494 NCIT_R122 NCIT_C17021 @default.
- NCIT_C494 NCIT_R122 NCIT_C17573 @default.
- NCIT_C494 NCIT_R122 NCIT_C20027 @default.
- NCIT_C494 NCIT_R122 NCIT_C26548 @default.
- NCIT_C494 NCIT_R122 NCIT_C28459 @default.
- NCIT_C494 NCIT_R122 NCIT_C45999 @default.
- NCIT_C494 NCIT_R122 NCIT_C46000 @default.
- NCIT_C494 normalizedInformationContent "100" @default.
- NCIT_C494 referenceCount "1" @default.
- NCIT_C494 hasExactSynonym "Abstral" @default.
- NCIT_C494 hasExactSynonym "Duragesic" @default.
- NCIT_C494 hasExactSynonym "FENTANYL" @default.
- NCIT_C494 hasExactSynonym "Fentanyl" @default.
- NCIT_C494 hasExactSynonym "N-(1-phenethylpiperidin-4-yl)-N-phenylpropionamide" @default.
- NCIT_C494 inSubset NCIT_C116977 @default.
- NCIT_C494 inSubset NCIT_C116978 @default.
- NCIT_C494 inSubset NCIT_C63923 @default.
- NCIT_C494 type Class @default.
- NCIT_C494 isDefinedBy ncit.owl @default.
- NCIT_C494 label "Fentanyl" @default.
- NCIT_C494 subClassOf B065ebb281856e81aa07ba695f1e5c672 @default.
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- NCIT_C494 subClassOf NCIT_C1506 @default.
- NCIT_C494 subClassOf NCIT_C1908 @default.
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- NCIT_C494 subClassOf NCIT_C1916 @default.
- NCIT_C494 subClassOf NCIT_C221 @default.
- NCIT_C494 subClassOf NCIT_C494 @default.
- NCIT_C494 subClassOf NCIT_C67413 @default.
- NCIT_C494 subClassOf NCIT_C718 @default.
- NCIT_C494 subClassOf NCIT_C78272 @default.