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- NCIT_C49424 IAO_0000115 "Human TP73 wild-type allele is located in the vicinity of 1p36.33 and is approximately 1 kb in length. This allele, which encodes tumor protein p73, plays a role in the cell cycle and is frequently deleted in neuroblastoma and other cancers." @default.
- NCIT_C49424 NCIT_NHC0 "C49424" @default.
- NCIT_C49424 NCIT_P100 "601990" @default.
- NCIT_C49424 NCIT_P102 "NM_005427" @default.
- NCIT_C49424 NCIT_P102 "Y11416" @default.
- NCIT_C49424 NCIT_P106 "Gene or Genome" @default.
- NCIT_C49424 NCIT_P108 "TP73 wt Allele" @default.
- NCIT_C49424 NCIT_P207 "C1710313" @default.
- NCIT_C49424 NCIT_P211 "DNA damage response, signal transduction resulting in induction of apoptosis" @default.
- NCIT_C49424 NCIT_P211 "mismatch repair" @default.
- NCIT_C49424 NCIT_P211 "transcription factor activity" @default.
- NCIT_C49424 NCIT_P321 "7161" @default.
- NCIT_C49424 NCIT_P366 "TP73_wt_Allele" @default.
- NCIT_C49424 NCIT_P96 "TP73 Protein" @default.
- NCIT_C49424 NCIT_P98 "The tumor suppressor TP73 gene encodes a 73 kD protein with sequence similarity to p53. p53 residues implicated in DNA binding are conserved in p73, which appears to activate some p53-responsive genes and to induce apoptosis. p73 and c-ABL may participate in a mismatch repair-dependent pro-apoptotic signaling pathway. T-cells undergoing TCR-AICD, in a late G1 cell-cycle checkpoint, are dependent on E2F1 and TP73. Expression of E2F1 causes accumulation of p73." @default.
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- NCIT_C49424 hasExactSynonym "TP73 wt Allele" @default.
- NCIT_C49424 hasExactSynonym "TRP73, Mouse, Homolog of Gene" @default.
- NCIT_C49424 hasExactSynonym "Tumor Protein p73 wt Allele" @default.
- NCIT_C49424 type Class @default.
- NCIT_C49424 isDefinedBy ncit.owl @default.
- NCIT_C49424 label "TP73 wt Allele" @default.
- NCIT_C49424 subClassOf NCIT_C16612 @default.
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