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NCIT_C49511 IAO_0000115 "Human CDKN2A wild-type allele is located in the vicinity of 9p21 and is approximately 27 kb in length. This allele, which encodes both cyclin-dependent kinase inhibitor 2A protein and and tumor suppressor ARF protein, is involved in cell cycle regulation at the G1 phase. The allele is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene." @default.
NCIT_C49511 NCIT_NHC0 "C49511" @default.
NCIT_C49511 NCIT_P100 "600160" @default.
NCIT_C49511 NCIT_P102 "L27211" @default.
NCIT_C49511 NCIT_P102 "NM_000077" @default.
NCIT_C49511 NCIT_P106 "Gene or Genome" @default.
NCIT_C49511 NCIT_P107 "CDKN2A wt Allele" @default.
NCIT_C49511 NCIT_P108 "CDKN2A wt Allele" @default.
NCIT_C49511 NCIT_P207 "C1705280" @default.
NCIT_C49511 NCIT_P211 "cell cycle arrest" @default.
NCIT_C49511 NCIT_P211 "cell cycle checkpoint" @default.
NCIT_C49511 NCIT_P211 "cell cycle" @default.
NCIT_C49511 NCIT_P211 "cellular_component unknown" @default.
NCIT_C49511 NCIT_P211 "cyclin-dependent protein kinase inhibitor activity" @default.
NCIT_C49511 NCIT_P211 "negative regulation of cell proliferation" @default.
NCIT_C49511 NCIT_P211 "nucleus" @default.
NCIT_C49511 NCIT_P211 "regulation of CDK activity" @default.
NCIT_C49511 NCIT_P321 "1029" @default.
NCIT_C49511 NCIT_P322 "CTRP" @default.
NCIT_C49511 NCIT_P366 "CDKN2A_wt_Allele" @default.
NCIT_C49511 NCIT_P96 "Cyclin-Dependent Kinase Inhibitor 2A" @default.
NCIT_C49511 NCIT_P98 "CDKN2A disruptions such as chromosomal inversions, translocations, and deletions are associated with malignancies and in a variety of malignant cell lines from glioma, non-small cell lung cancer, leukemia, melanoma and tumors of the breast, bone, skin, bladder, kidney, and ovary. Three alternatively spliced variants that encode distinct proteins have been reported in the literature, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants." @default.
NCIT_C49511 NCIT_R130 NCIT_C18611 @default.
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