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- NCIT_C501 IAO_0000115 "A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis." @default.
- NCIT_C501 NCIT_NHC0 "C501" @default.
- NCIT_C501 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C501 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C501 NCIT_P107 "Flucytosine" @default.
- NCIT_C501 NCIT_P108 "Flucytosine" @default.
- NCIT_C501 NCIT_P175 "103805" @default.
- NCIT_C501 NCIT_P207 "C0016278" @default.
- NCIT_C501 NCIT_P210 "2022-85-7" @default.
- NCIT_C501 NCIT_P319 "D83282DT06" @default.
- NCIT_C501 NCIT_P322 "CTRP" @default.
- NCIT_C501 NCIT_P322 "FDA" @default.
- NCIT_C501 NCIT_P325 "A drug that treats infections caused by fungi." @default.
- NCIT_C501 NCIT_P329 "41023" @default.
- NCIT_C501 NCIT_P330 "41023" @default.
- NCIT_C501 NCIT_P350 "C4H4FN3O" @default.
- NCIT_C501 NCIT_P366 "Flucytosine" @default.
- NCIT_C501 NCIT_P368 "CHEBI:5100" @default.
- NCIT_C501 NCIT_P399 "41023" @default.
- NCIT_C501 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C501 referenceCount "2" @default.
- NCIT_C501 hasExactSynonym "4-Amino-5-fluoro-2(1H)-pyrimidinone" @default.
- NCIT_C501 hasExactSynonym "5-FC" @default.
- NCIT_C501 hasExactSynonym "5-Fluorocytosine" @default.
- NCIT_C501 hasExactSynonym "Alcobon" @default.
- NCIT_C501 hasExactSynonym "Ancobon" @default.
- NCIT_C501 hasExactSynonym "Ancotil" @default.
- NCIT_C501 hasExactSynonym "FLUCYTOSINE" @default.
- NCIT_C501 hasExactSynonym "Flucytosine" @default.
- NCIT_C501 hasExactSynonym "Ro 2-9915" @default.
- NCIT_C501 hasExactSynonym "Ro-2-9915" @default.
- NCIT_C501 hasExactSynonym "flucytosine" @default.
- NCIT_C501 inSubset NCIT_C116977 @default.
- NCIT_C501 inSubset NCIT_C116978 @default.
- NCIT_C501 inSubset NCIT_C176424 @default.
- NCIT_C501 inSubset NCIT_C63923 @default.
- NCIT_C501 type Class @default.
- NCIT_C501 isDefinedBy ncit.owl @default.
- NCIT_C501 label "Flucytosine" @default.
- NCIT_C501 subClassOf NCIT_C1908 @default.
- NCIT_C501 subClassOf NCIT_C1909 @default.
- NCIT_C501 subClassOf NCIT_C254 @default.
- NCIT_C501 subClassOf NCIT_C501 @default.
- NCIT_C501 subClassOf NCIT_C514 @default.