Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C506> ?p ?o ?g. }
Showing items 1 to 53 of
53
with 100 items per page.
- NCIT_C506 IAO_0000115 "A diphenhydramine derivative and selective serotonin reuptake inhibitor with antidepressant, anti-anxiety, antiobsessional and antibulimic activity and with potential immunomodulating activity. Upon administration, fluoxetine binds to the presynaptic serotonin (5-HT) receptor resulting in negative allosteric modulation of the receptor complex, thereby blocking recycling of serotonin by the presynaptic receptor. Inhibition of serotonin reuptake by fluoxetine enhances serotonergic function through serotonin accumulation in the synaptic space, resulting in long-term desensitization and downregulation of 5-HT receptors, preventing 5-HT-mediated signaling and leading to antidepressant, anti-anxiety, antiobsessional and antibulimic effects. In addition, fluoxetine may inhibit the expression of pro-inflammatory cytokines, including interleukin-6 (IL-6). This may prevent IL-6-mediated inflammation and cytokine storm." @default.
- NCIT_C506 NCIT_A5 NCIT_C2829 @default.
- NCIT_C506 NCIT_A5 NCIT_C61807 @default.
- NCIT_C506 NCIT_NHC0 "C506" @default.
- NCIT_C506 NCIT_P106 "Organic Chemical" @default.
- NCIT_C506 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C506 NCIT_P108 "Fluoxetine" @default.
- NCIT_C506 NCIT_P207 "C0016365" @default.
- NCIT_C506 NCIT_P210 "54910-89-3" @default.
- NCIT_C506 NCIT_P302 "Depression" @default.
- NCIT_C506 NCIT_P319 "01K63SUP8D" @default.
- NCIT_C506 NCIT_P322 "FDA" @default.
- NCIT_C506 NCIT_P325 "A drug used to treat depression. It belongs to the family of drugs called antidepressants." @default.
- NCIT_C506 NCIT_P329 "41578" @default.
- NCIT_C506 NCIT_P330 "41578" @default.
- NCIT_C506 NCIT_P350 "C17H18F3NO" @default.
- NCIT_C506 NCIT_P366 "Fluoxetine" @default.
- NCIT_C506 NCIT_P368 "CHEBI:5118" @default.
- NCIT_C506 NCIT_P399 "41578" @default.
- NCIT_C506 NCIT_R122 NCIT_C16484 @default.
- NCIT_C506 NCIT_R122 NCIT_C16486 @default.
- NCIT_C506 NCIT_R122 NCIT_C16554 @default.
- NCIT_C506 NCIT_R122 NCIT_C16865 @default.
- NCIT_C506 NCIT_R122 NCIT_C16946 @default.
- NCIT_C506 NCIT_R122 NCIT_C17021 @default.
- NCIT_C506 NCIT_R122 NCIT_C17287 @default.
- NCIT_C506 NCIT_R122 NCIT_C20027 @default.
- NCIT_C506 NCIT_R122 NCIT_C26548 @default.
- NCIT_C506 NCIT_R122 NCIT_C28459 @default.
- NCIT_C506 NCIT_R122 NCIT_C28750 @default.
- NCIT_C506 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C506 referenceCount "2" @default.
- NCIT_C506 hasExactSynonym "FLUOXETINE" @default.
- NCIT_C506 hasExactSynonym "Fluoxetine" @default.
- NCIT_C506 hasExactSynonym "N-methyl-gamma-(4-(trifluoromethyl) -phenoxy)-benzenepropanamine" @default.
- NCIT_C506 hasExactSynonym "fluoxetine" @default.
- NCIT_C506 inSubset NCIT_C173381 @default.
- NCIT_C506 inSubset NCIT_C173383 @default.
- NCIT_C506 inSubset NCIT_C176424 @default.
- NCIT_C506 inSubset NCIT_C63923 @default.
- NCIT_C506 type Class @default.
- NCIT_C506 isDefinedBy ncit.owl @default.
- NCIT_C506 label "Fluoxetine" @default.
- NCIT_C506 subClassOf B01ef08306ca17858632288e0323a37f5 @default.
- NCIT_C506 subClassOf B65973a3f644e43038bf8a9f0d20cc9dc @default.
- NCIT_C506 subClassOf B988e93427f2117f130b1fc700a90aff3 @default.
- NCIT_C506 subClassOf Bb6a8e64aab2c6d8945fbba3d39ac8f15 @default.
- NCIT_C506 subClassOf NCIT_C1908 @default.
- NCIT_C506 subClassOf NCIT_C1909 @default.
- NCIT_C506 subClassOf NCIT_C265 @default.
- NCIT_C506 subClassOf NCIT_C506 @default.
- NCIT_C506 subClassOf NCIT_C78272 @default.
- NCIT_C506 subClassOf NCIT_C94725 @default.