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- NCIT_C508 IAO_0000115 "A derivative of propionic acid, and a phenylalkanoic acid derivative of non-steroidal antiinflammatory drugs (NSAIDs) with analgesic, antiinflammatory and antipyretic effects. Flurbiprofen non-selectively binds to and inhibits cyclooxygenase (COX). This results in a reduction of arachidonic acid conversion into prostaglandins that are involved in the regulation of pain, inflammation and fever. This NSAID also inhibits carbonic anhydrase, thereby reducing the production of hydrogen and bicarbonate ions. Upon ocular administration, flurbiprofen may reduce bicarbonate ion concentrations leading to a decrease in the production of aqueous humor, thereby lowering intraocular pressure." @default.
- NCIT_C508 NCIT_A5 NCIT_C47997 @default.
- NCIT_C508 NCIT_NHC0 "C508" @default.
- NCIT_C508 NCIT_P106 "Organic Chemical" @default.
- NCIT_C508 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C508 NCIT_P108 "Flurbiprofen" @default.
- NCIT_C508 NCIT_P175 "685701" @default.
- NCIT_C508 NCIT_P207 "C0016377" @default.
- NCIT_C508 NCIT_P210 "5104-49-4" @default.
- NCIT_C508 NCIT_P319 "5GRO578KLP" @default.
- NCIT_C508 NCIT_P322 "FDA" @default.
- NCIT_C508 NCIT_P329 "39245" @default.
- NCIT_C508 NCIT_P330 "39245" @default.
- NCIT_C508 NCIT_P350 "C15H13FO2" @default.
- NCIT_C508 NCIT_P366 "Flurbiprofen" @default.
- NCIT_C508 NCIT_P368 "CHEBI:5130" @default.
- NCIT_C508 NCIT_P399 "39245" @default.
- NCIT_C508 normalizedInformationContent "100" @default.
- NCIT_C508 referenceCount "1" @default.
- NCIT_C508 hasExactSynonym "2-Fluoro-alpha-methyl[1,1'-biphenyl]-4-acetic Acid" @default.
- NCIT_C508 hasExactSynonym "Ansaid" @default.
- NCIT_C508 hasExactSynonym "BTS 18,322" @default.
- NCIT_C508 hasExactSynonym "FLURBIPROFEN" @default.
- NCIT_C508 hasExactSynonym "Flurbiprofen" @default.
- NCIT_C508 hasExactSynonym "U-27,182" @default.
- NCIT_C508 inSubset NCIT_C176424 @default.
- NCIT_C508 inSubset NCIT_C63923 @default.
- NCIT_C508 type Class @default.
- NCIT_C508 isDefinedBy ncit.owl @default.
- NCIT_C508 label "Flurbiprofen" @default.
- NCIT_C508 subClassOf NCIT_C1323 @default.
- NCIT_C508 subClassOf NCIT_C1908 @default.
- NCIT_C508 subClassOf NCIT_C1909 @default.
- NCIT_C508 subClassOf NCIT_C2198 @default.
- NCIT_C508 subClassOf NCIT_C2356 @default.
- NCIT_C508 subClassOf NCIT_C241 @default.
- NCIT_C508 subClassOf NCIT_C257 @default.
- NCIT_C508 subClassOf NCIT_C29577 @default.
- NCIT_C508 subClassOf NCIT_C471 @default.
- NCIT_C508 subClassOf NCIT_C508 @default.
- NCIT_C508 subClassOf NCIT_C78272 @default.