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- NCIT_C50878 IAO_0000115 "Human DPYD wild-type allele is located within 1p22 and is approximately 843 kb in length. This allele, which encodes dihydropyrimidine dehydrogenase [NADP+] protein, plays a role in the reduction of uracil, thymine and the drug 5-fluorouracil. Hereditary defects in the DPYD gene cause an error in pyrimidine metabolism associated with both thymine-uraciluria and increased toxicity of 5-fluorouracil during chemotherapy." @default.
- NCIT_C50878 NCIT_NHC0 "C50878" @default.
- NCIT_C50878 NCIT_P100 "612779" @default.
- NCIT_C50878 NCIT_P102 "NM_000110" @default.
- NCIT_C50878 NCIT_P106 "Gene or Genome" @default.
- NCIT_C50878 NCIT_P107 "DPYD wt Allele" @default.
- NCIT_C50878 NCIT_P108 "DPYD wt Allele" @default.
- NCIT_C50878 NCIT_P207 "C1704716" @default.
- NCIT_C50878 NCIT_P211 "cytoplasm" @default.
- NCIT_C50878 NCIT_P211 "dihydropyrimidine dehydrogenase activity" @default.
- NCIT_C50878 NCIT_P211 "thymidine catabolism" @default.
- NCIT_C50878 NCIT_P211 "uracil catabolism" @default.
- NCIT_C50878 NCIT_P321 "1806" @default.
- NCIT_C50878 NCIT_P322 "CTRP" @default.
- NCIT_C50878 NCIT_P366 "DPYD_wt_Allele" @default.
- NCIT_C50878 NCIT_P96 "Dihydropyrimidine Dehydrogenase" @default.
- NCIT_C50878 NCIT_P98 "Increased levels of dihydropyrimidine dehydrogenase [NADP+] alter the efficacy of 5-fluorouracil-based chemotherapy via increased inactivation of this agent in tumor cells. Levels of DPYD mRNA in cancerous tissues seem to correlate with tumor progression. In both liver metastasis and advanced colorectal cancer, high DPYD mRNA levels may be clinically important with respect to 5-fluorouracil-based chemosensitivity." @default.
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- NCIT_C50878 hasExactSynonym "DHP" @default.
- NCIT_C50878 hasExactSynonym "DHPDHASE" @default.
- NCIT_C50878 hasExactSynonym "DPD" @default.
- NCIT_C50878 hasExactSynonym "DPYD wt Allele" @default.
- NCIT_C50878 hasExactSynonym "Dihydropyrimidine Dehydrogenase wt Allele" @default.
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- NCIT_C50878 type Class @default.
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- NCIT_C50878 label "DPYD wt Allele" @default.
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