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• NCIT_C51075 IAO_0000115 "Human HLA-A wild-type allele is located in the vicinity of 6p21.3 and is approximately 3 kb in length. This allele, which encodes HLA class I histocompatibility antigen, A-1 alpha chain protein, is involved in immune system peptide presentation." @default.
• NCIT_C51075 NCIT_NHC0 "C51075" @default.
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• NCIT_C51075 NCIT_P102 "NM_002116" @default.
• NCIT_C51075 NCIT_P106 "Gene or Genome" @default.
• NCIT_C51075 NCIT_P107 "HLA-A wt Allele" @default.
• NCIT_C51075 NCIT_P108 "HLA-A wt Allele" @default.
• NCIT_C51075 NCIT_P207 "C1708276" @default.
• NCIT_C51075 NCIT_P211 "MHC class I receptor activity" @default.
• NCIT_C51075 NCIT_P211 "immune response" @default.
• NCIT_C51075 NCIT_P211 "integral to plasma membrane" @default.
• NCIT_C51075 NCIT_P321 "3105" @default.
• NCIT_C51075 NCIT_P322 "CTRP" @default.
• NCIT_C51075 NCIT_P366 "HLA-A_wt_Allele" @default.
• NCIT_C51075 NCIT_P96 "HLA-A2 Antigen" @default.
• NCIT_C51075 NCIT_P98 "The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. Polymorphic alpha1/2 determines peptide binding specificity. Ig-like alpha3 mediates CD8 binding on cytotoxic T-lymphocytes. In the immune response, HLA antigens mediate antigen presentation to TCR. HLA-A2 subtypes are associated with decreased risk of HIV-1 infection and increased frequency of early-onset Alzheimer disease." @default.
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• NCIT_C51075 hasExactSynonym "HLA-A wt Allele" @default.
• NCIT_C51075 hasExactSynonym "HLAA" @default.

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