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- NCIT_C51207 IAO_0000115 "Human IRAK1 wild-type allele is located within Xq28 and is approximately 9 kb in length. This allele, which encodes interleukin-1 receptor-associated kinase 1 protein, is involved both in interleukin-1-induced up-regulation of the transcription factor NF-kappa B and in regulation of responsiveness to bacterial endotoxins." @default.
- NCIT_C51207 NCIT_NHC0 "C51207" @default.
- NCIT_C51207 NCIT_P100 "300283" @default.
- NCIT_C51207 NCIT_P102 "NM_001569" @default.
- NCIT_C51207 NCIT_P106 "Gene or Genome" @default.
- NCIT_C51207 NCIT_P107 "IRAK1 wt Allele" @default.
- NCIT_C51207 NCIT_P108 "IRAK1 wt Allele" @default.
- NCIT_C51207 NCIT_P207 "C1708448" @default.
- NCIT_C51207 NCIT_P211 "NF-kappaB-inducing kinase activity" @default.
- NCIT_C51207 NCIT_P211 "defense response" @default.
- NCIT_C51207 NCIT_P211 "interleukin-1 receptor complex" @default.
- NCIT_C51207 NCIT_P211 "protein amino acid phosphorylation" @default.
- NCIT_C51207 NCIT_P211 "protein binding" @default.
- NCIT_C51207 NCIT_P211 "signal transduction" @default.
- NCIT_C51207 NCIT_P321 "3654" @default.
- NCIT_C51207 NCIT_P322 "CTRP" @default.
- NCIT_C51207 NCIT_P366 "IRAK1_wt_Allele" @default.
- NCIT_C51207 NCIT_P96 "Interleukin-1 Receptor-Associated Kinase 1" @default.
- NCIT_C51207 NCIT_P98 "The IRAK1 gene has been shown to produce a splice variant, IRAK1c, which lacks a region of exon 11 typically encoded by the gene. The resulting protein lacks kinase activity, cannot be phosphorylated and yet retains the protein binding ability of the major isoform. Overexpression of IRAK1c suppresses activation of NF-kappa B and blocks both IL-6 and TNF-alpha production." @default.
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- NCIT_C51207 referenceCount "1" @default.
- NCIT_C51207 hasExactSynonym "IRAK" @default.
- NCIT_C51207 hasExactSynonym "IRAK1 wt Allele" @default.
- NCIT_C51207 hasExactSynonym "Interleukin 1 Receptor Associated Kinase 1 wt Allele" @default.
- NCIT_C51207 hasExactSynonym "Interleukin-1 Receptor-Associated Kinase 1 Gene" @default.
- NCIT_C51207 hasExactSynonym "pelle" @default.
- NCIT_C51207 inSubset NCIT_C116977 @default.
- NCIT_C51207 inSubset NCIT_C142799 @default.
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- NCIT_C51207 type Class @default.
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- NCIT_C51207 label "IRAK1 wt Allele" @default.
- NCIT_C51207 subClassOf NCIT_C16612 @default.
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- NCIT_C51207 equivalentClass Bd69551993f231618e20edd1d50126dd5 @default.