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- NCIT_C51210 IAO_0000115 "Human LATS1 wild-type allele is located within 6q24-q25.1 and is approximately 108 kb in length. This allele, which encodes serine/threonine-protein kinase LATS1 protein, plays a role in cell cycle regulation and cytokinesis. Down-regulation of LATS1 gene expression by promoter hypermethylation is associated with an aggressive phenotype in breast cancer." @default.
- NCIT_C51210 NCIT_NHC0 "C51210" @default.
- NCIT_C51210 NCIT_P100 "603473" @default.
- NCIT_C51210 NCIT_P102 "NM_004690" @default.
- NCIT_C51210 NCIT_P106 "Gene or Genome" @default.
- NCIT_C51210 NCIT_P108 "LATS1 wt Allele" @default.
- NCIT_C51210 NCIT_P207 "C1705714" @default.
- NCIT_C51210 NCIT_P211 "cell proliferation" @default.
- NCIT_C51210 NCIT_P211 "protein serine/threonine kinase activity" @default.
- NCIT_C51210 NCIT_P211 "regulation of cell cycle" @default.
- NCIT_C51210 NCIT_P211 "regulation of mitosis" @default.
- NCIT_C51210 NCIT_P321 "9113" @default.
- NCIT_C51210 NCIT_P366 "LATS1_wt_Allele" @default.
- NCIT_C51210 NCIT_P96 "Large Tumor Suppressor Homolog 1" @default.
- NCIT_C51210 NCIT_P98 "The LATS1 gene is widely expressed in both fetal and adult tissues. Serine/threonine-protein kinase LATS1 protein is a tumor suppressor protein that functions to maintain ploidy by means of its action at the G1 tetraploidy checkpoint, negative regulation of the G2/M transition and inhibition of mitotic progression. This protein also regulates expression of the TP53 tumor suppressor gene." @default.
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- NCIT_C51210 normalizedInformationContent "100" @default.
- NCIT_C51210 referenceCount "1" @default.
- NCIT_C51210 hasExactSynonym "LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) wt Allele" @default.
- NCIT_C51210 hasExactSynonym "LATS1 wt Allele" @default.
- NCIT_C51210 hasExactSynonym "WARTS" @default.
- NCIT_C51210 hasExactSynonym "WTS" @default.
- NCIT_C51210 type Class @default.
- NCIT_C51210 isDefinedBy ncit.owl @default.
- NCIT_C51210 label "LATS1 wt Allele" @default.
- NCIT_C51210 subClassOf NCIT_C16612 @default.
- NCIT_C51210 subClassOf NCIT_C20194 @default.
- NCIT_C51210 subClassOf NCIT_C21281 @default.
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- NCIT_C51210 equivalentClass Bfe131d7da8c0c4317889fb00e2abd219 @default.