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- NCIT_C51211 IAO_0000115 "Human LATS2 wild-type allele is located within 13q11-q12 and is approximately 87 kb in length. This allele, which encodes serine/threonine-protein kinase LATS2 protein, is involved in centrosome duplication and the maintenance of mitotic fidelity. Down-regulation of LATS1 gene expression by promoter hypermethylation is associated with an aggressive phenotype in breast cancer." @default.
- NCIT_C51211 NCIT_NHC0 "C51211" @default.
- NCIT_C51211 NCIT_P100 "604861" @default.
- NCIT_C51211 NCIT_P102 "NM_014572" @default.
- NCIT_C51211 NCIT_P106 "Gene or Genome" @default.
- NCIT_C51211 NCIT_P108 "LATS2 wt Allele" @default.
- NCIT_C51211 NCIT_P207 "C1708617" @default.
- NCIT_C51211 NCIT_P211 "ATP binding" @default.
- NCIT_C51211 NCIT_P211 "nucleus" @default.
- NCIT_C51211 NCIT_P211 "protein amino acid phosphorylation" @default.
- NCIT_C51211 NCIT_P211 "protein serine/threonine kinase activity" @default.
- NCIT_C51211 NCIT_P321 "26524" @default.
- NCIT_C51211 NCIT_P366 "LATS2_wt_Allele" @default.
- NCIT_C51211 NCIT_P96 "Large Tumor Suppressor Homolog 2" @default.
- NCIT_C51211 NCIT_P98 "The LATS2 gene is expressed in many tissues, although the highest levels of gene products are detected in the heart and skeletal muscle. This gene produces two RNA transcript variants via alternative splicing, which are approximately 3.8 kb and 5.8 kb in length. The shorter of the two transcripts is only expressed in the testis. Serine/threonine-protein kinase LATS2 protein is a negative regulator of the G1/S transition. It is also involved in the inhibition of androgen receptor function." @default.
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- NCIT_C51211 normalizedInformationContent "100" @default.
- NCIT_C51211 referenceCount "1" @default.
- NCIT_C51211 hasExactSynonym "LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) wt Allele" @default.
- NCIT_C51211 hasExactSynonym "LATS2 wt Allele" @default.
- NCIT_C51211 type Class @default.
- NCIT_C51211 isDefinedBy ncit.owl @default.
- NCIT_C51211 label "LATS2 wt Allele" @default.
- NCIT_C51211 subClassOf NCIT_C16612 @default.
- NCIT_C51211 subClassOf NCIT_C20194 @default.
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- NCIT_C51211 subClassOf NCIT_C24542 @default.
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- NCIT_C51211 subClassOf NCIT_C25871 @default.
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